| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARFIP2 | ARL1 | ENSP00000484121 | ENSP00000261636 | Arfaptin-2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling; Classical BAR domain containing | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | 0.998 |
| ARFIP2 | SCOC | ENSP00000484121 | ENSP00000477352 | Arfaptin-2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling; Classical BAR domain containing | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.591 |
| ARFRP1 | ARL1 | ENSP00000483486 | ENSP00000261636 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver; ARF GTPase family | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | 0.933 |
| ARFRP1 | SCOC | ENSP00000483486 | ENSP00000477352 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver; ARF GTPase family | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.645 |
| ARL1 | ARFIP2 | ENSP00000261636 | ENSP00000484121 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Arfaptin-2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling; Classical BAR domain containing | 0.998 |
| ARL1 | ARFRP1 | ENSP00000261636 | ENSP00000483486 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver; ARF GTPase family | 0.933 |
| ARL1 | SCOC | ENSP00000261636 | ENSP00000477352 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.957 |
| ARL3 | SCOC | ENSP00000260746 | ENSP00000477352 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.588 |
| ARL3 | UNC119 | ENSP00000260746 | ENSP00000337040 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Prob [...] | 0.924 |
| FEZ1 | SCOC | ENSP00000278919 | ENSP00000477352 | Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules; Belongs to the zygin family | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.958 |
| FEZ1 | UNC119 | ENSP00000278919 | ENSP00000337040 | Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules; Belongs to the zygin family | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Prob [...] | 0.731 |
| FEZ2 | SCOC | ENSP00000368547 | ENSP00000477352 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.948 |
| FEZ2 | UNC119 | ENSP00000368547 | ENSP00000337040 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Prob [...] | 0.453 |
| GDPD3 | SCOC | ENSP00000384363 | ENSP00000477352 | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | 0.530 |
| GDPD3 | SPINK2 | ENSP00000384363 | ENSP00000425961 | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) and lysophosphatidylcholine (lyso-PC), and to a lesser extent for lysophosphatidylethanolamine (lyso-PE). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine | Serine peptidase inhibitor, Kazal type 2 | 0.603 |
| SCOC | ARFIP2 | ENSP00000477352 | ENSP00000484121 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | Arfaptin-2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling; Classical BAR domain containing | 0.591 |
| SCOC | ARFRP1 | ENSP00000477352 | ENSP00000483486 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver; ARF GTPase family | 0.645 |
| SCOC | ARL1 | ENSP00000477352 | ENSP00000261636 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | 0.957 |
| SCOC | ARL3 | ENSP00000477352 | ENSP00000260746 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | 0.588 |
| SCOC | FEZ1 | ENSP00000477352 | ENSP00000278919 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family | Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules; Belongs to the zygin family | 0.958 |
