| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A4GALT | XKR7 | ENSP00000384794 | ENSP00000477059 | Lactosylceramide 4-alpha-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins; Alpha 1,4-glycosyltransferases | XK-related protein 7; XK related family | 0.476 |
| CCM2L | DUSP15 | ENSP00000262659 | ENSP00000341658 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases | 0.566 |
| CCM2L | KIF3B | ENSP00000262659 | ENSP00000364864 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | 0.508 |
| CCM2L | POFUT1 | ENSP00000262659 | ENSP00000364902 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.581 |
| CCM2L | XKR7 | ENSP00000262659 | ENSP00000477059 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | XK-related protein 7; XK related family | 0.712 |
| DUSP15 | CCM2L | ENSP00000341658 | ENSP00000262659 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.566 |
| DUSP15 | XKR7 | ENSP00000341658 | ENSP00000477059 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases | XK-related protein 7; XK related family | 0.645 |
| EPB41L1 | XKR7 | ENSP00000337168 | ENSP00000477059 | Band 4.1-like protein 1; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases; Erythrocyte membrane protein band 4.1 | XK-related protein 7; XK related family | 0.590 |
| KIF3B | CCM2L | ENSP00000364864 | ENSP00000262659 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.508 |
| KIF3B | POFUT1 | ENSP00000364864 | ENSP00000364902 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | 0.535 |
| KIF3B | XKR7 | ENSP00000364864 | ENSP00000477059 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | XK-related protein 7; XK related family | 0.494 |
| POFUT1 | CCM2L | ENSP00000364902 | ENSP00000262659 | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein | 0.581 |
| POFUT1 | KIF3B | ENSP00000364902 | ENSP00000364864 | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Kinesins | 0.535 |
| POFUT1 | XKR7 | ENSP00000364902 | ENSP00000477059 | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can [...] | XK-related protein 7; XK related family | 0.588 |
| STOX2 | TSPAN33 | ENSP00000311257 | ENSP00000483872 | Storkhead-box protein 2; Storkhead box 2 | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity; Belongs to the tetraspanin (TM4SF) family | 0.443 |
| STOX2 | XKR7 | ENSP00000311257 | ENSP00000477059 | Storkhead-box protein 2; Storkhead box 2 | XK-related protein 7; XK related family | 0.470 |
| SYT4 | XKR7 | ENSP00000255224 | ENSP00000477059 | Synaptotagmin-4; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family | XK-related protein 7; XK related family | 0.539 |
| TSPAN33 | STOX2 | ENSP00000483872 | ENSP00000311257 | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity; Belongs to the tetraspanin (TM4SF) family | Storkhead-box protein 2; Storkhead box 2 | 0.443 |
| TSPAN33 | XKR7 | ENSP00000483872 | ENSP00000477059 | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity; Belongs to the tetraspanin (TM4SF) family | XK-related protein 7; XK related family | 0.453 |
| WNK2 | XKR7 | ENSP00000297954 | ENSP00000477059 | Serine/threonine-protein kinase WNK2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulatio [...] | XK-related protein 7; XK related family | 0.475 |
