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  • 11.0 [archived version]
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ZNF16 ZNF16 ZNF35 ZNF35 TP53BP1 TP53BP1 ZFP82 ZFP82 ZBTB25 ZBTB25 ZNF555 ZNF555 WNK1 WNK1 ELP6 ELP6 ZNF45 ZNF45 ZNF696 ZNF696 TCFL5 TCFL5
"ZBTB25" - Zinc finger and BTB domain-containing protein 25 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
ZBTB25Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing (435 aa)    
Predicted Functional Partners:
TP53BP1
TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] (1977 aa)
       
      0.677
WNK1
Serine/threonine-protein kinase WNK1; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thia [...] (2634 aa)
           
  0.670
TCFL5
Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis; Basic helix-loop-helix proteins (500 aa)
           
  0.606
ZNF16
Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family (682 aa)
           
  0.538
ZFP82
Zinc finger protein 82 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type (532 aa)
     
   
  0.538
ELP6
Elongator complex protein 6; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (266 aa)
       
      0.534
ZNF555
Zinc finger protein 555; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (628 aa)
           
  0.528
ZNF696
Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type (374 aa)
           
  0.505
ZNF35
Zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation; Zinc fingers C2H2-type (527 aa)
           
  0.501
ZNF45
Zinc finger protein 45; May be involved in transcriptional regulation; Zinc fingers C2H2-type (682 aa)
           
  0.498
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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