node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ELP6 | ZBTB25 | ENSP00000296149 | ENSP00000476746 | Elongator complex protein 6; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.534 |
TCFL5 | ZBTB25 | ENSP00000334294 | ENSP00000476746 | Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis; Basic helix-loop-helix proteins | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.606 |
TP53BP1 | ZBTB25 | ENSP00000371475 | ENSP00000476746 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.677 |
WNK1 | ZBTB25 | ENSP00000341292 | ENSP00000476746 | Serine/threonine-protein kinase WNK1; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thia [...] | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.670 |
ZBTB25 | ELP6 | ENSP00000476746 | ENSP00000296149 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Elongator complex protein 6; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration | 0.534 |
ZBTB25 | TCFL5 | ENSP00000476746 | ENSP00000334294 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis; Basic helix-loop-helix proteins | 0.606 |
ZBTB25 | TP53BP1 | ENSP00000476746 | ENSP00000371475 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.677 |
ZBTB25 | WNK1 | ENSP00000476746 | ENSP00000341292 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Serine/threonine-protein kinase WNK1; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thia [...] | 0.670 |
ZBTB25 | ZFP82 | ENSP00000476746 | ENSP00000431265 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 82 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.538 |
ZBTB25 | ZNF16 | ENSP00000476746 | ENSP00000276816 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.538 |
ZBTB25 | ZNF35 | ENSP00000476746 | ENSP00000379368 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation; Zinc fingers C2H2-type | 0.501 |
ZBTB25 | ZNF45 | ENSP00000476746 | ENSP00000269973 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 45; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.498 |
ZBTB25 | ZNF555 | ENSP00000476746 | ENSP00000334853 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 555; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.528 |
ZBTB25 | ZNF696 | ENSP00000476746 | ENSP00000328515 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.505 |
ZFP82 | ZBTB25 | ENSP00000431265 | ENSP00000476746 | Zinc finger protein 82 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.538 |
ZNF16 | ZBTB25 | ENSP00000276816 | ENSP00000476746 | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.538 |
ZNF35 | ZBTB25 | ENSP00000379368 | ENSP00000476746 | Zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation; Zinc fingers C2H2-type | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.501 |
ZNF45 | ZBTB25 | ENSP00000269973 | ENSP00000476746 | Zinc finger protein 45; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.498 |
ZNF555 | ZBTB25 | ENSP00000334853 | ENSP00000476746 | Zinc finger protein 555; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.528 |
ZNF696 | ZBTB25 | ENSP00000328515 | ENSP00000476746 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing | 0.505 |