node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GNAO1 | GNAZ | ENSP00000262494 | ENSP00000478892 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily | Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.913 |
GNAO1 | GPRIN3 | ENSP00000262494 | ENSP00000476603 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | 0.529 |
GNAO1 | SYNGAP1 | ENSP00000262494 | ENSP00000403636 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily | Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity); C2 and [...] | 0.434 |
GNAZ | GNAO1 | ENSP00000478892 | ENSP00000262494 | Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.913 |
GNAZ | GPRIN3 | ENSP00000478892 | ENSP00000476603 | Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | 0.640 |
GPRIN3 | GNAO1 | ENSP00000476603 | ENSP00000262494 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.529 |
GPRIN3 | GNAZ | ENSP00000476603 | ENSP00000478892 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.640 |
GPRIN3 | GRM2 | ENSP00000476603 | ENSP00000378492 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization; Glutamate metabotropic receptors | 0.485 |
GPRIN3 | MAP6 | ENSP00000476603 | ENSP00000307093 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B | 0.518 |
GPRIN3 | MMRN1 | ENSP00000476603 | ENSP00000378431 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein; EMI domain containing | 0.557 |
GPRIN3 | SH2D5 | ENSP00000476603 | ENSP00000406026 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels | 0.520 |
GPRIN3 | SYNGAP1 | ENSP00000476603 | ENSP00000403636 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity); C2 and [...] | 0.480 |
GPRIN3 | TIGD2 | ENSP00000476603 | ENSP00000317170 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Tigger transposable element-derived protein 2; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.556 |
GPRIN3 | WIZ | ENSP00000476603 | ENSP00000263381 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity); Zinc fingers C2H2-type | 0.754 |
GPRIN3 | ZNF644 | ENSP00000476603 | ENSP00000337008 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | Zinc finger protein 644; May be involved in transcriptional regulation | 0.725 |
GRM2 | GPRIN3 | ENSP00000378492 | ENSP00000476603 | Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization; Glutamate metabotropic receptors | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | 0.485 |
GRM2 | SYNGAP1 | ENSP00000378492 | ENSP00000403636 | Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization; Glutamate metabotropic receptors | Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity); C2 and [...] | 0.514 |
MAP6 | GPRIN3 | ENSP00000307093 | ENSP00000476603 | Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | 0.518 |
MMRN1 | GPRIN3 | ENSP00000378431 | ENSP00000476603 | Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein; EMI domain containing | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth | 0.557 |
MMRN1 | TIGD2 | ENSP00000378431 | ENSP00000317170 | Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein; EMI domain containing | Tigger transposable element-derived protein 2; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.470 |