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  • 11.0 [archived version]
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MMRN1 MMRN1 MAP6 MAP6 TIGD2 TIGD2 SH2D5 SH2D5 GPRIN3 GPRIN3 GRM2 GRM2 WIZ WIZ ZNF644 ZNF644 SYNGAP1 SYNGAP1 GNAO1 GNAO1 GNAZ GNAZ
"GPRIN3" - G protein-regulated inducer of neurite outgrowth 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
GPRIN3G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth (776 aa)    
Predicted Functional Partners:
WIZ
Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity); Zinc fingers C2H2-type (794 aa)
           
  0.754
ZNF644
Zinc finger protein 644; May be involved in transcriptional regulation (1327 aa)
           
  0.725
GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (355 aa)
           
  0.640
MMRN1
Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein; EMI domain containing (1228 aa)
           
  0.557
TIGD2
Tigger transposable element-derived protein 2; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes (525 aa)
           
  0.556
GNAO1
Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14; Belongs to the G-alpha family. G(i/o/t/z) subfamily (354 aa)
           
  0.529
SH2D5
SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels (423 aa)
           
  0.520
MAP6
Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (813 aa)
           
  0.518
GRM2
Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization; Glutamate metabotropic receptors (872 aa)
           
  0.485
SYNGAP1
Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity); C2 and [...] (1343 aa)
           
  0.480
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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