• Version:
  • 11.0 [archived version]
STRINGSTRING
TAGLN2 TAGLN2 COL1A1 COL1A1 MKX MKX SOX9 SOX9 TNMD TNMD SCX SCX GDF7 GDF7 DCN DCN ALB ALB CCL26 CCL26 PRDM10 PRDM10
"SCX" - Basic helix-loop-helix transcription factor scleraxis in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SCXBasic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages; Basic helix-loop-helix proteins (201 aa)    
Predicted Functional Partners:
TNMD
Tenomodulin; May be an angiogenesis inhibitor; BRICHOS domain containing (317 aa)
           
  0.911
SOX9
Transcription factor SOX-9; Transcriptional regulator. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). Plays a role in chondrocyte differentiation (By similarity). Important for normal skeletal development; SRY-boxes (509 aa)
       
 
  0.747
MKX
Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion; TALE class homeoboxes and pseudogenes (352 aa)
       
 
  0.664
COL1A1
Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Collagens (1464 aa)
     
   
  0.615
CCL26
C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils; Belongs to the intercrine beta (chemokine CC) family (94 aa)
           
  0.588
TAGLN2
Transgelin-2; Transgelin 2 (220 aa)
           
  0.586
GDF7
Growth/differentiation factor 7; May play an active role in the motor area of the primate neocortex (450 aa)
           
  0.581
ALB
Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc; Belongs to the ALB/AFP/VDB family (609 aa)
           
  0.571
DCN
Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans (359 aa)
           
  0.566
PRDM10
PR domain zinc finger protein 10; May be involved in transcriptional regulation; PR/SET domain family (1160 aa)
       
 
  0.557
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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