node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | CDYL2 | ENSP00000333664 | ENSP00000476295 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Chromodomain Y like 2 | 0.541 |
ACAA1 | SCP2 | ENSP00000333664 | ENSP00000360569 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis | 0.882 |
CDYL2 | ACAA1 | ENSP00000476295 | ENSP00000333664 | Chromodomain Y like 2 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 0.541 |
CDYL2 | CLEC3A | ENSP00000476295 | ENSP00000299642 | Chromodomain Y like 2 | C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing | 0.640 |
CDYL2 | DICER1 | ENSP00000476295 | ENSP00000437256 | Chromodomain Y like 2 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3’ overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, a [...] | 0.558 |
CDYL2 | POLA1 | ENSP00000476295 | ENSP00000368349 | Chromodomain Y like 2 | DNA polymerase alpha catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase [...] | 0.594 |
CDYL2 | PSMB1 | ENSP00000476295 | ENSP00000262193 | Chromodomain Y like 2 | Proteasome subunit beta type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | 0.537 |
CDYL2 | PTPN13 | ENSP00000476295 | ENSP00000394794 | Chromodomain Y like 2 | Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2; FERM domain containing | 0.540 |
CDYL2 | SCP2 | ENSP00000476295 | ENSP00000360569 | Chromodomain Y like 2 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis | 0.628 |
CDYL2 | TDRD7 | ENSP00000476295 | ENSP00000347444 | Chromodomain Y like 2 | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes- probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family | 0.563 |
CDYL2 | TGIF2LX | ENSP00000476295 | ENSP00000453704 | Chromodomain Y like 2 | Homeobox protein TGIF2LX; May have a transcription role in testis; TALE class homeoboxes and pseudogenes | 0.654 |
CDYL2 | TNRC6B | ENSP00000476295 | ENSP00000401946 | Chromodomain Y like 2 | Trinucleotide repeat-containing gene 6B protein; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes; Armadillo-like helical domain containing | 0.533 |
CLEC3A | CDYL2 | ENSP00000299642 | ENSP00000476295 | C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing | Chromodomain Y like 2 | 0.640 |
DICER1 | CDYL2 | ENSP00000437256 | ENSP00000476295 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3’ overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, a [...] | Chromodomain Y like 2 | 0.558 |
DICER1 | TNRC6B | ENSP00000437256 | ENSP00000401946 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3’ overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA- induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, a [...] | Trinucleotide repeat-containing gene 6B protein; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes; Armadillo-like helical domain containing | 0.633 |
POLA1 | CDYL2 | ENSP00000368349 | ENSP00000476295 | DNA polymerase alpha catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase [...] | Chromodomain Y like 2 | 0.594 |
PSMB1 | CDYL2 | ENSP00000262193 | ENSP00000476295 | Proteasome subunit beta type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing prot [...] | Chromodomain Y like 2 | 0.537 |
PTPN13 | CDYL2 | ENSP00000394794 | ENSP00000476295 | Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2; FERM domain containing | Chromodomain Y like 2 | 0.540 |
PTPN13 | TGIF2LX | ENSP00000394794 | ENSP00000453704 | Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2; FERM domain containing | Homeobox protein TGIF2LX; May have a transcription role in testis; TALE class homeoboxes and pseudogenes | 0.444 |
SCP2 | ACAA1 | ENSP00000360569 | ENSP00000333664 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 0.882 |