TM2D1 protein (human) - STRING database

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TM2D1

TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42 (207 aa)

Predicted Functional Partners:

TM2D2

0.931

FGGY

0.578

PAG1

0.535

FUT11

0.530

EVA1B

0.518

FAM53A

0.507

SERPINF2

0.495

SPG21

0.484

HOOK1

0.466

UTP11L

0.458

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EVA1B	TM2D1	ENSP00000270824	ENSP00000475700	Eva-1 homolog B; Belongs to the EVA1 family	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.518
FAM53A	FUT11	ENSP00000310057	ENSP00000361932	Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle	Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases	0.504
FAM53A	TM2D1	ENSP00000310057	ENSP00000475700	Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.507
FGGY	HOOK1	ENSP00000360262	ENSP00000360252	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)	0.507
FGGY	TM2D1	ENSP00000360262	ENSP00000475700	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.578
FUT11	FAM53A	ENSP00000361932	ENSP00000310057	Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases	Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle	0.504
FUT11	TM2D1	ENSP00000361932	ENSP00000475700	Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.530
HOOK1	FGGY	ENSP00000360252	ENSP00000360262	Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	0.507
HOOK1	TM2D1	ENSP00000360252	ENSP00000475700	Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.466
PAG1	SERPINF2	ENSP00000220597	ENSP00000321853	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling	Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin; Serpin peptidase inhibitors	0.493
PAG1	TM2D1	ENSP00000220597	ENSP00000475700	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.535
SERPINF2	PAG1	ENSP00000321853	ENSP00000220597	Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin; Serpin peptidase inhibitors	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling	0.493
SERPINF2	TM2D1	ENSP00000321853	ENSP00000475700	Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin; Serpin peptidase inhibitors	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.495
SPG21	TM2D1	ENSP00000204566	ENSP00000475700	Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	0.484
TM2D1	EVA1B	ENSP00000475700	ENSP00000270824	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	Eva-1 homolog B; Belongs to the EVA1 family	0.518
TM2D1	FAM53A	ENSP00000475700	ENSP00000310057	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle	0.507
TM2D1	FGGY	ENSP00000475700	ENSP00000360262	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family	0.578
TM2D1	FUT11	ENSP00000475700	ENSP00000361932	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases	0.530
TM2D1	HOOK1	ENSP00000475700	ENSP00000360252	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex)	0.466
TM2D1	PAG1	ENSP00000475700	ENSP00000220597	TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling	0.535

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