KPRP protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

KPRP

Keratinocyte proline rich protein (579 aa)

Predicted Functional Partners:

KRT78

0.963

LMOD1

0.748

SPRR4

0.737

CRNN

0.691

TCHHL1

0.662

RPTN

0.659

LELP1

0.650

S100A2

0.646

LCE2B

0.642

S100A3

0.637

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRNN	KPRP	ENSP00000271835	ENSP00000475216	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Keratinocyte proline rich protein	0.691
CRNN	RPTN	ENSP00000271835	ENSP00000317895	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing	0.490
CRNN	TCHHL1	ENSP00000271835	ENSP00000357796	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	S100 fused type protein family; Belongs to the S-100 family	0.408
KPRP	CRNN	ENSP00000475216	ENSP00000271835	Keratinocyte proline rich protein	Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest; Belongs to the S100-fused protein family	0.691
KPRP	KRT78	ENSP00000475216	ENSP00000306261	Keratinocyte proline rich protein	Keratin, type II cytoskeletal 78; Keratins, type II	0.963
KPRP	LCE2B	ENSP00000475216	ENSP00000357769	Keratinocyte proline rich protein	Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum	0.642
KPRP	LELP1	ENSP00000475216	ENSP00000357736	Keratinocyte proline rich protein	Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family	0.650
KPRP	LMOD1	ENSP00000475216	ENSP00000356257	Keratinocyte proline rich protein	Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family	0.748
KPRP	RPTN	ENSP00000475216	ENSP00000317895	Keratinocyte proline rich protein	Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing	0.659
KPRP	S100A2	ENSP00000475216	ENSP00000357697	Keratinocyte proline rich protein	Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth; EF-hand domain containing	0.646
KPRP	S100A3	ENSP00000475216	ENSP00000357702	Keratinocyte proline rich protein	Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins	0.637
KPRP	SPRR4	ENSP00000475216	ENSP00000332163	Keratinocyte proline rich protein	Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family	0.737
KPRP	TCHHL1	ENSP00000475216	ENSP00000357796	Keratinocyte proline rich protein	S100 fused type protein family; Belongs to the S-100 family	0.662
KRT78	KPRP	ENSP00000306261	ENSP00000475216	Keratin, type II cytoskeletal 78; Keratins, type II	Keratinocyte proline rich protein	0.963
LCE2B	KPRP	ENSP00000357769	ENSP00000475216	Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum	Keratinocyte proline rich protein	0.642
LCE2B	LELP1	ENSP00000357769	ENSP00000357736	Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum	Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family	0.916
LCE2B	RPTN	ENSP00000357769	ENSP00000317895	Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum	Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing	0.929
LCE2B	SPRR4	ENSP00000357769	ENSP00000332163	Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum	Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family	0.480
LELP1	KPRP	ENSP00000357736	ENSP00000475216	Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family	Keratinocyte proline rich protein	0.650
LELP1	LCE2B	ENSP00000357736	ENSP00000357769	Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family	Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum	0.916

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