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  • 11.0 [archived version]
STRINGSTRING
SYNE3 SYNE3 C6orf141 C6orf141 CEACAM20 CEACAM20 CNNM1 CNNM1 PDCL3 PDCL3 SMAGP SMAGP CMTM4 CMTM4 COLGALT2 COLGALT2 COL26A1 COL26A1 MITD1 MITD1 TSNAXIP1 TSNAXIP1
"SMAGP" - Small cell adhesion glycoprotein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SMAGPSmall cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation (97 aa)    
Predicted Functional Partners:
TSNAXIP1
Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis (712 aa)
            
  0.621
C6orf141
Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 (244 aa)
            
  0.567
MITD1
MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex (249 aa)
            
  0.565
PDCL3
Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family (239 aa)
            
  0.546
SYNE3
Nesprin-3; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is re [...] (975 aa)
            
  0.522
COLGALT2
Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen; Belongs to the glycosyltransferase 25 family (626 aa)
            
  0.502
CNNM1
Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family (951 aa)
            
  0.502
CEACAM20
Carcinoembryonic antigen-related cell adhesion molecule 20; Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response; Belongs to the immunoglobulin superfamily. CEA family (596 aa)
            
  0.499
CMTM4
CKLF like MARVEL transmembrane domain containing 4 (234 aa)
            
  0.496
COL26A1
Collagen type XXVI alpha 1 chain; Collagens (441 aa)
            
  0.483
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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