| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF5 | CTAGE6 | ENSP00000056217 | ENSP00000474388 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | CTAGE family member 6 | 0.511 |
| ARHGEF5 | TISP43 | ENSP00000056217 | ENSP00000387081 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | Uncharacterized LOC150527 | 0.448 |
| CTAGE5 | CTAGE6 | ENSP00000379462 | ENSP00000474388 | Endoplasmic reticulum export factor CTAGE5; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites; CTAGE family | CTAGE family member 6 | 0.734 |
| CTAGE5 | MIA3 | ENSP00000379462 | ENSP00000340900 | Endoplasmic reticulum export factor CTAGE5; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites; CTAGE family | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | 0.988 |
| CTAGE6 | ARHGEF5 | ENSP00000474388 | ENSP00000056217 | CTAGE family member 6 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | 0.511 |
| CTAGE6 | CTAGE5 | ENSP00000474388 | ENSP00000379462 | CTAGE family member 6 | Endoplasmic reticulum export factor CTAGE5; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites; CTAGE family | 0.734 |
| CTAGE6 | FAM115A | ENSP00000474388 | ENSP00000419235 | CTAGE family member 6 | TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner | 0.653 |
| CTAGE6 | FAM115C | ENSP00000474388 | ENSP00000412724 | CTAGE family member 6 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | 0.588 |
| CTAGE6 | HIST2H2BF | ENSP00000474388 | ENSP00000445831 | CTAGE family member 6 | Histone H2B type 2-F; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.418 |
| CTAGE6 | MIA3 | ENSP00000474388 | ENSP00000340900 | CTAGE family member 6 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | 0.837 |
| CTAGE6 | POM121L2 | ENSP00000474388 | ENSP00000392726 | CTAGE family member 6 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | 0.443 |
| CTAGE6 | SPDYE1 | ENSP00000474388 | ENSP00000258704 | CTAGE family member 6 | Speedy protein E1; speedy/RINGO cell cycle regulator family member E1 | 0.441 |
| CTAGE6 | SPDYE2 | ENSP00000474388 | ENSP00000421686 | CTAGE family member 6 | Speedy protein E2; speedy/RINGO cell cycle regulator family member E2; Belongs to the Speedy/Ringo family | 0.426 |
| CTAGE6 | TISP43 | ENSP00000474388 | ENSP00000387081 | CTAGE family member 6 | Uncharacterized LOC150527 | 0.553 |
| FAM115A | CTAGE6 | ENSP00000419235 | ENSP00000474388 | TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner | CTAGE family member 6 | 0.653 |
| FAM115A | TISP43 | ENSP00000419235 | ENSP00000387081 | TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner | Uncharacterized LOC150527 | 0.576 |
| FAM115C | CTAGE6 | ENSP00000412724 | ENSP00000474388 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | CTAGE family member 6 | 0.588 |
| FAM115C | TISP43 | ENSP00000412724 | ENSP00000387081 | TRPM8 channel-associated factor 2; Isoform 2- Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner | Uncharacterized LOC150527 | 0.543 |
| HIST2H2BF | CTAGE6 | ENSP00000445831 | ENSP00000474388 | Histone H2B type 2-F; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | CTAGE family member 6 | 0.418 |
| MIA3 | CTAGE5 | ENSP00000340900 | ENSP00000379462 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] | Endoplasmic reticulum export factor CTAGE5; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites; CTAGE family | 0.988 |
