IZUMO3 protein (human) - STRING database

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IZUMO3

Izumo sperm-egg fusion protein 3; IZUMO family member 3 (233 aa)

Predicted Functional Partners:

CD9

0.921

IZUMO4

0.861

IZUMO2

0.857

IZUMO1

0.726

ADAM32

0.721

FOLR4

0.678

ADAM2

0.676

ISOC2

0.633

FOLR3

0.541

CPED1

0.537

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM2	CD9	ENSP00000265708	ENSP00000371958	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	0.695
ADAM2	IZUMO1	ENSP00000265708	ENSP00000327786	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’	0.668
ADAM2	IZUMO2	ENSP00000265708	ENSP00000293405	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.672
ADAM2	IZUMO3	ENSP00000265708	ENSP00000474246	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.676
ADAM2	IZUMO4	ENSP00000265708	ENSP00000378712	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.536
ADAM32	IZUMO2	ENSP00000369238	ENSP00000293405	Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.689
ADAM32	IZUMO3	ENSP00000369238	ENSP00000474246	Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.721
ADAM32	IZUMO4	ENSP00000369238	ENSP00000378712	Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.588
CD9	ADAM2	ENSP00000371958	ENSP00000265708	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	0.695
CD9	FOLR4	ENSP00000371958	ENSP00000332963	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’. Does not bind folate	0.516
CD9	IZUMO1	ENSP00000371958	ENSP00000327786	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’	0.966
CD9	IZUMO2	ENSP00000371958	ENSP00000293405	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.910
CD9	IZUMO3	ENSP00000371958	ENSP00000474246	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.921
CD9	IZUMO4	ENSP00000371958	ENSP00000378712	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.942
CPED1	IZUMO3	ENSP00000309772	ENSP00000474246	Cadherin like and PC-esterase domain containing 1	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.537
FOLR3	IZUMO3	ENSP00000481114	ENSP00000474246	Folate receptor gamma; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.541
FOLR3	IZUMO4	ENSP00000481114	ENSP00000378712	Folate receptor gamma; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.550
FOLR4	CD9	ENSP00000332963	ENSP00000371958	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’. Does not bind folate	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	0.516
FOLR4	IZUMO1	ENSP00000332963	ENSP00000327786	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’. Does not bind folate	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’	0.977
FOLR4	IZUMO2	ENSP00000332963	ENSP00000293405	Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’. Does not bind folate	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.409

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