node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPTF | DIDO1 | ENSP00000307208 | ENSP00000266070 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins | 0.706 |
BPTF | LEKR1 | ENSP00000307208 | ENSP00000474182 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | 0.861 |
DIDO1 | BPTF | ENSP00000266070 | ENSP00000307208 | Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.706 |
DIDO1 | LEKR1 | ENSP00000266070 | ENSP00000474182 | Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | 0.719 |
GALNT10 | LEKR1 | ENSP00000297107 | ENSP00000474182 | Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates; Polypeptide N-acetylgalactosaminyltransferases | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | 0.600 |
GLE1 | LEKR1 | ENSP00000308622 | ENSP00000474182 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | 0.599 |
GLE1 | NUP107 | ENSP00000308622 | ENSP00000229179 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC; Belongs to the nucleoporin Nup84/Nup107 family | 0.990 |
GLE1 | NUP153 | ENSP00000308622 | ENSP00000444029 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.988 |
GLE1 | NUP155 | ENSP00000308622 | ENSP00000231498 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport | 0.993 |
GLE1 | NUP205 | ENSP00000308622 | ENSP00000285968 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armadillo-like helical domain containing | 0.972 |
LEKR1 | BPTF | ENSP00000474182 | ENSP00000307208 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.861 |
LEKR1 | DIDO1 | ENSP00000474182 | ENSP00000266070 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD finger proteins | 0.719 |
LEKR1 | GALNT10 | ENSP00000474182 | ENSP00000297107 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates; Polypeptide N-acetylgalactosaminyltransferases | 0.600 |
LEKR1 | GLE1 | ENSP00000474182 | ENSP00000308622 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC); Belongs to the GLE1 family | 0.599 |
LEKR1 | MAD1L1 | ENSP00000474182 | ENSP00000385334 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding | 0.656 |
LEKR1 | NUP107 | ENSP00000474182 | ENSP00000229179 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC; Belongs to the nucleoporin Nup84/Nup107 family | 0.652 |
LEKR1 | NUP153 | ENSP00000474182 | ENSP00000444029 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. [...] | 0.680 |
LEKR1 | NUP155 | ENSP00000474182 | ENSP00000231498 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport | 0.628 |
LEKR1 | NUP205 | ENSP00000474182 | ENSP00000285968 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armadillo-like helical domain containing | 0.617 |
LEKR1 | SNCA | ENSP00000474182 | ENSP00000338345 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 | Alpha-synuclein; May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation; Parkinson disease associated genes | 0.628 |