MAGEA3 protein (human) - STRING database

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MAGEA3

Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MA [...] (314 aa)

Predicted Functional Partners:

GAGE2A

0.907

CSAG1

0.900

GAGE12F

0.890

BAGE5

0.882

CTAG1A

0.874

CTAG1B

0.871

GAGE1

0.839

PMEL

0.818

PRAME

0.799

MAGEA2

0.774

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAGE5	CTAG1A	ENSP00000485185	ENSP00000469441	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	0.710
BAGE5	CTAG1B	ENSP00000485185	ENSP00000332602	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	0.710
BAGE5	GAGE1	ENSP00000485185	ENSP00000484668	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	G antigen 1; Belongs to the GAGE family	0.905
BAGE5	GAGE12F	ENSP00000485185	ENSP00000404123	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	G antigen 12F; Belongs to the GAGE family	0.905
BAGE5	GAGE2A	ENSP00000485185	ENSP00000355421	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	G antigen 2A	0.906
BAGE5	MAGEA2	ENSP00000485185	ENSP00000485541	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...]	0.590
BAGE5	MAGEA3	ENSP00000485185	ENSP00000473093	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MA [...]	0.882
BAGE5	PMEL	ENSP00000485185	ENSP00000402758	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity	0.559
BAGE5	PRAME	ENSP00000485185	ENSP00000445675	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family	0.669
CSAG1	GAGE1	ENSP00000359310	ENSP00000484668	Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1	G antigen 1; Belongs to the GAGE family	0.442
CSAG1	GAGE12F	ENSP00000359310	ENSP00000404123	Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1	G antigen 12F; Belongs to the GAGE family	0.557
CSAG1	MAGEA2	ENSP00000359310	ENSP00000485541	Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1	Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...]	0.827
CSAG1	MAGEA3	ENSP00000359310	ENSP00000473093	Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1	Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MA [...]	0.900
CSAG1	PRAME	ENSP00000359310	ENSP00000445675	Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1	Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis; PRAME family	0.636
CTAG1A	BAGE5	ENSP00000469441	ENSP00000485185	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	B melanoma antigen 2; Unknown. Candidate gene encoding tumor antigens; Belongs to the BAGE family	0.710
CTAG1A	CTAG1B	ENSP00000469441	ENSP00000332602	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family	0.793
CTAG1A	GAGE1	ENSP00000469441	ENSP00000484668	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	G antigen 1; Belongs to the GAGE family	0.657
CTAG1A	GAGE12F	ENSP00000469441	ENSP00000404123	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	G antigen 12F; Belongs to the GAGE family	0.405
CTAG1A	GAGE2A	ENSP00000469441	ENSP00000355421	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	G antigen 2A	0.435
CTAG1A	MAGEA2	ENSP00000469441	ENSP00000485541	Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family	Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal d [...]	0.646

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