| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASK | PNMAL2 | ENSP00000367408 | ENSP00000473036 | Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1; In the N-terminal section; belongs to the protein kinase s [...] | Paraneoplastic antigen-like protein 8B; Paraneoplastic Ma antigen family-like 2 | 0.677 |
| ENO2 | ENSG00000266953 | ENSP00000437402 | ENSP00000468690 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Uncharacterized protein | 0.678 |
| ENO2 | GPI | ENSP00000437402 | ENSP00000405573 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.972 |
| ENO2 | PGK1 | ENSP00000437402 | ENSP00000362413 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility | 0.945 |
| ENO2 | PGK2 | ENSP00000437402 | ENSP00000305995 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.877 |
| ENO2 | PKLR | ENSP00000437402 | ENSP00000339933 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family | 0.980 |
| ENO2 | PKM | ENSP00000437402 | ENSP00000320171 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.981 |
| ENO2 | PNMAL2 | ENSP00000437402 | ENSP00000473036 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Paraneoplastic antigen-like protein 8B; Paraneoplastic Ma antigen family-like 2 | 0.662 |
| ENO2 | TPI1 | ENSP00000437402 | ENSP00000229270 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family | 0.955 |
| ENSG00000266953 | ENO2 | ENSP00000468690 | ENSP00000437402 | Uncharacterized protein | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | 0.678 |
| ENSG00000266953 | PGK1 | ENSP00000468690 | ENSP00000362413 | Uncharacterized protein | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility | 0.810 |
| ENSG00000266953 | PGK2 | ENSP00000468690 | ENSP00000305995 | Uncharacterized protein | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.810 |
| ENSG00000266953 | PKLR | ENSP00000468690 | ENSP00000339933 | Uncharacterized protein | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family | 0.775 |
| ENSG00000266953 | PKM | ENSP00000468690 | ENSP00000320171 | Uncharacterized protein | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.775 |
| ENSG00000266953 | PNMAL2 | ENSP00000468690 | ENSP00000473036 | Uncharacterized protein | Paraneoplastic antigen-like protein 8B; Paraneoplastic Ma antigen family-like 2 | 0.670 |
| ENSG00000266953 | TPI1 | ENSP00000468690 | ENSP00000229270 | Uncharacterized protein | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family | 0.915 |
| FAIM2 | PNMAL2 | ENSP00000321951 | ENSP00000473036 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development; Belongs to the BI1 family. LFG subfamily | Paraneoplastic antigen-like protein 8B; Paraneoplastic Ma antigen family-like 2 | 0.684 |
| GPI | ENO2 | ENSP00000405573 | ENSP00000437402 | Glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | 0.972 |
| GPI | PGK1 | ENSP00000405573 | ENSP00000362413 | Glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility | 0.957 |
| GPI | PGK2 | ENSP00000405573 | ENSP00000305995 | Glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.938 |
