• Version:
  • 11.0 [archived version]
STRINGSTRING
OR10S1 OR10S1 FAM135A FAM135A TRIM28 TRIM28 DEFB115 DEFB115 FSD1L FSD1L ZNF99 ZNF99 ASB7 ASB7 FAM179A FAM179A WDR63 WDR63 ORMDL1 ORMDL1 FAM133B FAM133B
"ZNF99" - Zinc finger protein 99 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF99Zinc finger protein 99; May be involved in transcriptional regulation; Zinc fingers C2H2-type (864 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.904
OR10S1
Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 (331 aa)
           
  0.550
DEFB115
Beta-defensin 115; Has antibacterial activity; Defensins, beta (88 aa)
           
  0.541
FAM179A
TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A (1019 aa)
     
   
  0.506
FAM133B
Protein FAM133B; Family with sequence similarity 133 member B (247 aa)
           
  0.473
FSD1L
FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like (530 aa)
     
 
  0.471
ASB7
Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family (318 aa)
     
 
  0.471
WDR63
WD repeat-containing protein 63; WD repeat domain containing (891 aa)
       
 
  0.448
FAM135A
Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family (1515 aa)
           
  0.442
ORMDL1
ORM1-like protein 1; Negative regulator of sphingolipid synthesis (153 aa)
       
 
  0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (2%) [HD]