| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCSAP | CXorf40B | ENSP00000284617 | ENSP00000359434 | Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity) | Protein CXorf40B; Chromosome X open reading frame 40B | 0.551 |
| CCSAP | ZIK1 | ENSP00000284617 | ENSP00000472867 | Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity) | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.478 |
| CXorf40B | CCSAP | ENSP00000359434 | ENSP00000284617 | Protein CXorf40B; Chromosome X open reading frame 40B | Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity) | 0.551 |
| CXorf40B | ZIK1 | ENSP00000359434 | ENSP00000472867 | Protein CXorf40B; Chromosome X open reading frame 40B | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.577 |
| GJA9 | ZIK1 | ENSP00000354020 | ENSP00000472867 | Gap junction alpha-9 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.549 |
| H2BFM | KRTAP6-3 | ENSP00000347119 | ENSP00000375482 | Histone H2B type F-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | Keratin-associated protein 6-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.474 |
| H2BFM | ZIK1 | ENSP00000347119 | ENSP00000472867 | Histone H2B type F-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.501 |
| KRTAP6-3 | H2BFM | ENSP00000375482 | ENSP00000347119 | Keratin-associated protein 6-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | Histone H2B type F-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.474 |
| KRTAP6-3 | ZIK1 | ENSP00000375482 | ENSP00000472867 | Keratin-associated protein 6-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.420 |
| PNMA3 | ZIK1 | ENSP00000469445 | ENSP00000472867 | Paraneoplastic Ma antigens; Belongs to the PNMA family | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.516 |
| PNMA5 | WFDC12 | ENSP00000388850 | ENSP00000361871 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | 0.537 |
| PNMA5 | ZIK1 | ENSP00000388850 | ENSP00000472867 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.569 |
| SDR42E1 | ZIK1 | ENSP00000332407 | ENSP00000472867 | Short chain dehydrogenase/reductase family 42E, member 1 | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.435 |
| TRIM28 | ZIK1 | ENSP00000253024 | ENSP00000472867 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.908 |
| WFDC12 | PNMA5 | ENSP00000361871 | ENSP00000388850 | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family | 0.537 |
| WFDC12 | ZIK1 | ENSP00000361871 | ENSP00000472867 | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | 0.448 |
| ZIK1 | CCSAP | ENSP00000472867 | ENSP00000284617 | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity) | 0.478 |
| ZIK1 | CXorf40B | ENSP00000472867 | ENSP00000359434 | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | Protein CXorf40B; Chromosome X open reading frame 40B | 0.577 |
| ZIK1 | GJA9 | ENSP00000472867 | ENSP00000354020 | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | Gap junction alpha-9 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell | 0.549 |
| ZIK1 | H2BFM | ENSP00000472867 | ENSP00000347119 | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type | Histone H2B type F-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | 0.501 |
