| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARL6 | ENSG00000268221 | ENSP00000337722 | ENSP00000472316 | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.635 |
| ARR3 | CRX | ENSP00000311538 | ENSP00000221996 | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | 0.680 |
| ARR3 | ENSG00000268221 | ENSP00000311538 | ENSP00000472316 | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.722 |
| ARR3 | GNAT1 | ENSP00000311538 | ENSP00000232461 | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins | Guanine nucleotide-binding protein G(t) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.544 |
| ARR3 | GNAT2 | ENSP00000311538 | ENSP00000251337 | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins | Guanine nucleotide-binding protein G(t) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.697 |
| CDR1 | ENSG00000268221 | ENSP00000359563 | ENSP00000472316 | Cerebellar degeneration related protein 1 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.711 |
| CDR1 | FRMD7 | ENSP00000359563 | ENSP00000298542 | Cerebellar degeneration related protein 1 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | 0.715 |
| CDR1 | NYX | ENSP00000359563 | ENSP00000340328 | Cerebellar degeneration related protein 1 | Nyctalopin | 0.641 |
| CDR1 | SLC25A14 | ENSP00000359563 | ENSP00000477981 | Cerebellar degeneration related protein 1 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.710 |
| CRX | ARR3 | ENSP00000221996 | ENSP00000311538 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins | 0.680 |
| CRX | ENSG00000268221 | ENSP00000221996 | ENSP00000472316 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | 0.639 |
| CRX | GNAT1 | ENSP00000221996 | ENSP00000232461 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | Guanine nucleotide-binding protein G(t) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.590 |
| CRX | GNAT2 | ENSP00000221996 | ENSP00000251337 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | Guanine nucleotide-binding protein G(t) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.618 |
| ENSG00000268221 | ARL6 | ENSP00000472316 | ENSP00000337722 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | 0.635 |
| ENSG00000268221 | ARR3 | ENSP00000472316 | ENSP00000311538 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins | 0.722 |
| ENSG00000268221 | CDR1 | ENSP00000472316 | ENSP00000359563 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | Cerebellar degeneration related protein 1 | 0.711 |
| ENSG00000268221 | CRX | ENSP00000472316 | ENSP00000221996 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | 0.639 |
| ENSG00000268221 | FRMD7 | ENSP00000472316 | ENSP00000298542 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domain containing | 0.710 |
| ENSG00000268221 | GNAT1 | ENSP00000472316 | ENSP00000232461 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | Guanine nucleotide-binding protein G(t) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.584 |
| ENSG00000268221 | GNAT2 | ENSP00000472316 | ENSP00000251337 | Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal | Guanine nucleotide-binding protein G(t) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | 0.673 |
