ZNF615 protein (human) - STRING database

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ZNF615

Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type (742 aa)

Predicted Functional Partners:

TRIM28

0.903

ANKRD33B

0.631

CCDC158

0.588

SDR42E1

0.520

MAP1LC3B2

0.496

THSD7B

0.445

EPS8L1

0.442

DCLK2

0.438

TUBD1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD33B	CCDC158	ENSP00000296657	ENSP00000373566	Ankyrin repeat domain-containing protein 33B; Ankyrin repeat domain containing	Coiled-coil domain containing 158	0.647
ANKRD33B	ZNF615	ENSP00000296657	ENSP00000471549	Ankyrin repeat domain-containing protein 33B; Ankyrin repeat domain containing	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.631
CCDC158	ANKRD33B	ENSP00000373566	ENSP00000296657	Coiled-coil domain containing 158	Ankyrin repeat domain-containing protein 33B; Ankyrin repeat domain containing	0.647
CCDC158	ZNF615	ENSP00000373566	ENSP00000471549	Coiled-coil domain containing 158	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.588
DCLK2	ZNF615	ENSP00000303887	ENSP00000471549	Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity); Doublecortin superfamily	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.438
EPS8L1	ZNF615	ENSP00000201647	ENSP00000471549	Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton; Belongs to the EPS8 family	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.442
MAP1LC3B2	ZNF615	ENSP00000450524	ENSP00000471549	Microtubule-associated proteins 1A/1B light chain 3 beta 2; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.496
SDR42E1	ZNF615	ENSP00000332407	ENSP00000471549	Short chain dehydrogenase/reductase family 42E, member 1	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.520
THSD7B	ZNF615	ENSP00000272643	ENSP00000471549	Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.445
TRIM28	ZNF615	ENSP00000253024	ENSP00000471549	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.903
TUBD1	ZNF615	ENSP00000320797	ENSP00000471549	Tubulin delta chain; In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head; Tubulins	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.405
ZNF615	ANKRD33B	ENSP00000471549	ENSP00000296657	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Ankyrin repeat domain-containing protein 33B; Ankyrin repeat domain containing	0.631
ZNF615	CCDC158	ENSP00000471549	ENSP00000373566	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Coiled-coil domain containing 158	0.588
ZNF615	DCLK2	ENSP00000471549	ENSP00000303887	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity); Doublecortin superfamily	0.438
ZNF615	EPS8L1	ENSP00000471549	ENSP00000201647	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton; Belongs to the EPS8 family	0.442
ZNF615	MAP1LC3B2	ENSP00000471549	ENSP00000450524	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Microtubule-associated proteins 1A/1B light chain 3 beta 2; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family	0.496
ZNF615	SDR42E1	ENSP00000471549	ENSP00000332407	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Short chain dehydrogenase/reductase family 42E, member 1	0.520
ZNF615	THSD7B	ENSP00000471549	ENSP00000272643	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B	0.445
ZNF615	TRIM28	ENSP00000471549	ENSP00000253024	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.903
ZNF615	TUBD1	ENSP00000471549	ENSP00000320797	Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Tubulin delta chain; In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head; Tubulins	0.405

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