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  • 11.0 [archived version]
STRINGSTRING
DNAJB11 DNAJB11 PFDN2 PFDN2 TRIM28 TRIM28 ZNF726 ZNF726 MYOT MYOT PARD6G PARD6G DEFB115 DEFB115 FAM135A FAM135A ASB7 ASB7 MTRNR2L12 MTRNR2L12 PRR32 PRR32
"ZNF726" - Zinc finger protein 726 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF726Zinc finger protein 726; May be involved in transcriptional regulation; Zinc fingers C2H2-type (616 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.904
DEFB115
Beta-defensin 115; Has antibacterial activity; Defensins, beta (88 aa)
           
  0.709
ASB7
Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family (318 aa)
     
 
  0.672
FAM135A
Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family (1515 aa)
           
  0.668
MTRNR2L12
Humanin-like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family (24 aa)
           
  0.559
PFDN2
Prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family (154 aa)
       
      0.548
PARD6G
Partitioning defective 6 homolog gamma; Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity); PDZ domain containing (376 aa)
           
  0.533
PRR32
Proline-rich protein 32; Proline rich 32 (298 aa)
           
  0.491
DNAJB11
DnaJ homolog subfamily B member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity; DNAJ heat shock proteins (358 aa)
       
 
  0.450
MYOT
Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing (498 aa)
           
  0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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