node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKAIP1 | CCDC124 | ENSP00000342676 | ENSP00000471455 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | 0.739 |
AURKAIP1 | CCDC77 | ENSP00000342676 | ENSP00000239830 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | Coiled-coil domain containing 77 | 0.727 |
AURKAIP1 | MRPL40 | ENSP00000342676 | ENSP00000333401 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | 0.993 |
AURKAIP1 | TUBGCP2 | ENSP00000342676 | ENSP00000446093 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.645 |
CCDC124 | AURKAIP1 | ENSP00000471455 | ENSP00000342676 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | 0.739 |
CCDC124 | CCDC77 | ENSP00000471455 | ENSP00000239830 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Coiled-coil domain containing 77 | 0.718 |
CCDC124 | EIF3J | ENSP00000471455 | ENSP00000261868 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.764 |
CCDC124 | MRPL40 | ENSP00000471455 | ENSP00000333401 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | 0.648 |
CCDC124 | PARPBP | ENSP00000471455 | ENSP00000332915 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect; Belongs to the PARI family | 0.669 |
CCDC124 | PRKRA | ENSP00000471455 | ENSP00000318176 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity i [...] | 0.742 |
CCDC124 | TGIF2LX | ENSP00000471455 | ENSP00000453704 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Homeobox protein TGIF2LX; May have a transcription role in testis; TALE class homeoboxes and pseudogenes | 0.626 |
CCDC124 | TUBGCP2 | ENSP00000471455 | ENSP00000446093 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.629 |
CCDC124 | UFSP2 | ENSP00000471455 | ENSP00000264689 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation; Belongs to the peptidase C78 family | 0.682 |
CCDC124 | ZNF346 | ENSP00000471455 | ENSP00000350869 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | Zinc finger protein 346; Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins | 0.742 |
CCDC77 | AURKAIP1 | ENSP00000239830 | ENSP00000342676 | Coiled-coil domain containing 77 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | 0.727 |
CCDC77 | CCDC124 | ENSP00000239830 | ENSP00000471455 | Coiled-coil domain containing 77 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | 0.718 |
CCDC77 | TUBGCP2 | ENSP00000239830 | ENSP00000446093 | Coiled-coil domain containing 77 | Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.680 |
EIF3J | CCDC124 | ENSP00000261868 | ENSP00000471455 | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2-GTP-methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | 0.764 |
MRPL40 | AURKAIP1 | ENSP00000333401 | ENSP00000342676 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation | 0.993 |
MRPL40 | CCDC124 | ENSP00000333401 | ENSP00000471455 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family | 0.648 |