• Version:
  • 11.0 [archived version]
STRINGSTRING
LRRCC1 LRRCC1 KIAA1328 KIAA1328 CCDC61 CCDC61 TTLL5 TTLL5 CEP135 CEP135 SSX2IP SSX2IP FOPNL FOPNL CCDC138 CCDC138 PIBF1 PIBF1 TBC1D31 TBC1D31 WDR90 WDR90
"CCDC61" - Coiled-coil domain containing 61 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CCDC61Coiled-coil domain containing 61 (512 aa)    
Predicted Functional Partners:
WDR90
WD repeat-containing protein 90; WD repeat domain containing (1748 aa)
     
   
  0.777
CCDC138
Coiled-coil domain containing 138 (665 aa)
           
  0.774
CEP135
Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family (1140 aa)
     
 
  0.769
KIAA1328
Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes (577 aa)
           
  0.766
PIBF1
Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (757 aa)
           
  0.746
TTLL5
Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family (1281 aa)
           
  0.729
SSX2IP
Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...] (614 aa)
     
   
  0.720
FOPNL
LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitement of PLK1 to centrosomes and S phase progression (174 aa)
           
  0.691
LRRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis (1032 aa)
           
  0.688
TBC1D31
TBC1 domain family member 31; WD repeat domain containing (1066 aa)
     
   
  0.676
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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