node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC138 | CCDC61 | ENSP00000295124 | ENSP00000471454 | Coiled-coil domain containing 138 | Coiled-coil domain containing 61 | 0.774 |
CCDC138 | KIAA1328 | ENSP00000295124 | ENSP00000280020 | Coiled-coil domain containing 138 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | 0.744 |
CCDC138 | PIBF1 | ENSP00000295124 | ENSP00000317144 | Coiled-coil domain containing 138 | Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 | 0.784 |
CCDC138 | SSX2IP | ENSP00000295124 | ENSP00000340279 | Coiled-coil domain containing 138 | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...] | 0.735 |
CCDC138 | TBC1D31 | ENSP00000295124 | ENSP00000287380 | Coiled-coil domain containing 138 | TBC1 domain family member 31; WD repeat domain containing | 0.662 |
CCDC138 | TTLL5 | ENSP00000295124 | ENSP00000298832 | Coiled-coil domain containing 138 | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.699 |
CCDC138 | WDR90 | ENSP00000295124 | ENSP00000293879 | Coiled-coil domain containing 138 | WD repeat-containing protein 90; WD repeat domain containing | 0.747 |
CCDC61 | CCDC138 | ENSP00000471454 | ENSP00000295124 | Coiled-coil domain containing 61 | Coiled-coil domain containing 138 | 0.774 |
CCDC61 | CEP135 | ENSP00000471454 | ENSP00000257287 | Coiled-coil domain containing 61 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family | 0.769 |
CCDC61 | FOPNL | ENSP00000471454 | ENSP00000255759 | Coiled-coil domain containing 61 | LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitement of PLK1 to centrosomes and S phase progression | 0.691 |
CCDC61 | KIAA1328 | ENSP00000471454 | ENSP00000280020 | Coiled-coil domain containing 61 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | 0.766 |
CCDC61 | LRRCC1 | ENSP00000471454 | ENSP00000353538 | Coiled-coil domain containing 61 | Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis | 0.688 |
CCDC61 | PIBF1 | ENSP00000471454 | ENSP00000317144 | Coiled-coil domain containing 61 | Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 | 0.746 |
CCDC61 | SSX2IP | ENSP00000471454 | ENSP00000340279 | Coiled-coil domain containing 61 | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...] | 0.720 |
CCDC61 | TBC1D31 | ENSP00000471454 | ENSP00000287380 | Coiled-coil domain containing 61 | TBC1 domain family member 31; WD repeat domain containing | 0.676 |
CCDC61 | TTLL5 | ENSP00000471454 | ENSP00000298832 | Coiled-coil domain containing 61 | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family | 0.729 |
CCDC61 | WDR90 | ENSP00000471454 | ENSP00000293879 | Coiled-coil domain containing 61 | WD repeat-containing protein 90; WD repeat domain containing | 0.777 |
CEP135 | CCDC61 | ENSP00000257287 | ENSP00000471454 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family | Coiled-coil domain containing 61 | 0.769 |
CEP135 | FOPNL | ENSP00000257287 | ENSP00000255759 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family | LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitement of PLK1 to centrosomes and S phase progression | 0.664 |
CEP135 | KIAA1328 | ENSP00000257287 | ENSP00000280020 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole; Belongs to the CEP135/TSGA10 family | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes | 0.560 |