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  • 11.0 [archived version]
STRINGSTRING
TMED7 TMED7 CHERP CHERP LYAR LYAR SLC35E1 SLC35E1 CIB3 CIB3 NR2C2AP NR2C2AP ENSG00000251201 ENSG00000251201 DDX49 DDX49 SLC25A42 SLC25A42 SLC39A3 SLC39A3 RFXANK RFXANK
"SLC35E1" - Solute carrier family 35 member E1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC35E1Solute carrier family 35 member E1; Putative transporter; Solute carriers (410 aa)    
Predicted Functional Partners:
NR2C2AP
Nuclear receptor 2C2-associated protein; May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes; Belongs to the NR2C2AP family (167 aa)
            
  0.719
SLC25A42
Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3’,5’- diphosphate; Solute carriers (318 aa)
      
   
  0.715
CHERP
Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing (916 aa)
      
   
  0.707
CIB3
Calcium and integrin binding family member 3; EF-hand domain containing (187 aa)
            
  0.696
DDX49
Probable ATP-dependent RNA helicase DDX49; DEAD-box helicase 49; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily (483 aa)
      
   
  0.674
ENSG00000251201
Transmembrane emp24 domain-containing protein 7; TMED7-TICAM2 readthrough (404 aa)
            
  0.638
TMED7
Transmembrane emp24 domain-containing protein 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post- translational modifications; Transmembrane p24 trafficking proteins (224 aa)
            
  0.629
LYAR
Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type (379 aa)
      
   
  0.628
SLC39A3
Zinc transporter ZIP3; Acts as a zinc-influx transporter; Solute carriers (314 aa)
      
   
  0.626
RFXANK
DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity); Ankyrin repeat domain containing (260 aa)
      
 
  0.599
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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