node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCDC2 | ZNF432 | ENSP00000367715 | ENSP00000470488 | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length; Deafness associated genes | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.516 |
GRIP2 | PAQR3 | ENSP00000480660 | ENSP00000421981 | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | 0.410 |
GRIP2 | PRKAR1B | ENSP00000480660 | ENSP00000385749 | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.447 |
GRIP2 | RHPN2 | ENSP00000480660 | ENSP00000254260 | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family | 0.450 |
GRIP2 | ZNF432 | ENSP00000480660 | ENSP00000470488 | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.449 |
IL36A | ZNF432 | ENSP00000259211 | ENSP00000470488 | Interleukin-36 alpha; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cel [...] | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.442 |
LILRA4 | ZNF432 | ENSP00000291759 | ENSP00000470488 | Leukocyte immunoglobulin-like receptor subfamily A member 4; Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine- phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down- regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex wit [...] | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.489 |
PAQR3 | GRIP2 | ENSP00000421981 | ENSP00000480660 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | 0.410 |
PAQR3 | PRKAR1B | ENSP00000421981 | ENSP00000385749 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.426 |
PAQR3 | PSMA2 | ENSP00000421981 | ENSP00000223321 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | Proteasome subunit alpha type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.420 |
PAQR3 | RHPN2 | ENSP00000421981 | ENSP00000254260 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family | 0.422 |
PAQR3 | ZNF432 | ENSP00000421981 | ENSP00000470488 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.491 |
PRKAR1B | GRIP2 | ENSP00000385749 | ENSP00000480660 | cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | 0.447 |
PRKAR1B | PAQR3 | ENSP00000385749 | ENSP00000421981 | cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | 0.426 |
PRKAR1B | ZNF432 | ENSP00000385749 | ENSP00000470488 | cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.455 |
PSMA2 | PAQR3 | ENSP00000223321 | ENSP00000421981 | Proteasome subunit alpha type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | 0.420 |
PSMA2 | ZNF432 | ENSP00000223321 | ENSP00000470488 | Proteasome subunit alpha type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.470 |
RHPN2 | GRIP2 | ENSP00000254260 | ENSP00000480660 | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons; PDZ domain containing | 0.450 |
RHPN2 | PAQR3 | ENSP00000254260 | ENSP00000421981 | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family | 0.422 |
RHPN2 | ZNF432 | ENSP00000254260 | ENSP00000470488 | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity; Belongs to the RHPN family | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.566 |