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STRINGSTRING
SUOX SUOX SORD SORD TMPRSS6 TMPRSS6 GRINA GRINA LOC388210 LOC388210 TM4SF4 TM4SF4 FTCD FTCD ALDH8A1 ALDH8A1 F13B F13B HRG HRG AGXT AGXT
"LOC388210" - Putative uncharacterized protein LOC400499 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC388210Putative uncharacterized protein LOC400499; Protein LOC101929274 (3231 aa)    
Predicted Functional Partners:
SUOX
Sulfite oxidase, mitochondrial; Sulfite oxidase (545 aa)
           
  0.450
GRINA
Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing (371 aa)
           
  0.450
SORD
Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm; Belongs to the zinc-containing alcohol dehydrogenase family (357 aa)
     
   
  0.445
TMPRSS6
Transmembrane protease serine 6; Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (824 aa)
     
 
  0.443
AGXT
Alanine-glyoxylate aminotransferase (392 aa)
     
   
  0.443
HRG
Histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell [...] (525 aa)
     
        0.443
ALDH8A1
Aldehyde dehydrogenase family 8 member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) (487 aa)
     
   
  0.434
F13B
Coagulation factor XIII B chain; The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin; Sushi domain containing (661 aa)
     
        0.433
TM4SF4
Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (202 aa)
     
        0.428
FTCD
Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family (541 aa)
     
        0.428
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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