node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACER1 | CKAP4 | ENSP00000301452 | ENSP00000367265 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | 0.499 |
ACER1 | CPTP | ENSP00000301452 | ENSP00000343890 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.547 |
ACER1 | LOC646862 | ENSP00000301452 | ENSP00000470441 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | RING finger protein 225; Uncharacterized protein LOC646862 | 0.451 |
ACER1 | SH3D21 | ENSP00000301452 | ENSP00000421294 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | SH3 domain containing 21 | 0.446 |
CAPN2 | LOC646862 | ENSP00000295006 | ENSP00000470441 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at ’Arg-226’. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity); Calpains | RING finger protein 225; Uncharacterized protein LOC646862 | 0.400 |
CAPN2 | SH3D21 | ENSP00000295006 | ENSP00000421294 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at ’Arg-226’. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity); Calpains | SH3 domain containing 21 | 0.415 |
CKAP4 | ACER1 | ENSP00000367265 | ENSP00000301452 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | 0.499 |
CKAP4 | CPTP | ENSP00000367265 | ENSP00000343890 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.494 |
CKAP4 | LOC646862 | ENSP00000367265 | ENSP00000470441 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | RING finger protein 225; Uncharacterized protein LOC646862 | 0.457 |
CKAP4 | SH3D21 | ENSP00000367265 | ENSP00000421294 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | SH3 domain containing 21 | 0.446 |
CPTP | ACER1 | ENSP00000343890 | ENSP00000301452 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | 0.547 |
CPTP | CKAP4 | ENSP00000343890 | ENSP00000367265 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | 0.494 |
CPTP | LOC646862 | ENSP00000343890 | ENSP00000470441 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | RING finger protein 225; Uncharacterized protein LOC646862 | 0.453 |
GRB2 | LOC646862 | ENSP00000376345 | ENSP00000470441 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | RING finger protein 225; Uncharacterized protein LOC646862 | 0.557 |
LOC646862 | ACER1 | ENSP00000470441 | ENSP00000301452 | RING finger protein 225; Uncharacterized protein LOC646862 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | 0.451 |
LOC646862 | CAPN2 | ENSP00000470441 | ENSP00000295006 | RING finger protein 225; Uncharacterized protein LOC646862 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at ’Arg-226’. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity); Calpains | 0.400 |
LOC646862 | CKAP4 | ENSP00000470441 | ENSP00000367265 | RING finger protein 225; Uncharacterized protein LOC646862 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | 0.457 |
LOC646862 | CPTP | ENSP00000470441 | ENSP00000343890 | RING finger protein 225; Uncharacterized protein LOC646862 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.453 |
LOC646862 | GRB2 | ENSP00000470441 | ENSP00000376345 | RING finger protein 225; Uncharacterized protein LOC646862 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | 0.557 |
LOC646862 | SH3D21 | ENSP00000470441 | ENSP00000421294 | RING finger protein 225; Uncharacterized protein LOC646862 | SH3 domain containing 21 | 0.452 |