| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C5orf63 | ZNF257 | ENSP00000454153 | ENSP00000470209 | Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.546 |
| CACHD1 | ZNF257 | ENSP00000290039 | ENSP00000470209 | VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.472 |
| FAM49B | ZNF257 | ENSP00000429150 | ENSP00000470209 | Protein FAM49B; Family with sequence similarity 49 member B | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.400 |
| SERAC1 | ZNF257 | ENSP00000356071 | ENSP00000470209 | Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36-1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway; Armadillo-like helical domain containing | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.420 |
| TRIM28 | ZNF257 | ENSP00000253024 | ENSP00000470209 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.904 |
| TSPAN3 | ZNF257 | ENSP00000267970 | ENSP00000470209 | Tetraspanin-3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair; Belongs to the tetraspanin (TM4SF) family | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.400 |
| UNC80 | ZNF257 | ENSP00000391088 | ENSP00000470209 | Protein unc-80 homolog; Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.416 |
| ZNF257 | C5orf63 | ENSP00000470209 | ENSP00000454153 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63 | 0.546 |
| ZNF257 | CACHD1 | ENSP00000470209 | ENSP00000290039 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels | 0.472 |
| ZNF257 | FAM49B | ENSP00000470209 | ENSP00000429150 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein FAM49B; Family with sequence similarity 49 member B | 0.400 |
| ZNF257 | SERAC1 | ENSP00000470209 | ENSP00000356071 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36-1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway; Armadillo-like helical domain containing | 0.420 |
| ZNF257 | TRIM28 | ENSP00000470209 | ENSP00000253024 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.904 |
| ZNF257 | TSPAN3 | ENSP00000470209 | ENSP00000267970 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Tetraspanin-3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair; Belongs to the tetraspanin (TM4SF) family | 0.400 |
| ZNF257 | UNC80 | ENSP00000470209 | ENSP00000391088 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein unc-80 homolog; Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium | 0.416 |
| ZNF257 | ZNF638 | ENSP00000470209 | ENSP00000386433 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Zinc finger protein 638; Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA. May also regulate alternative splicing of target genes during adipogenesis (By similarity); RNA binding motif containing | 0.402 |
| ZNF638 | ZNF257 | ENSP00000386433 | ENSP00000470209 | Zinc finger protein 638; Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (By similarity). Binds to cytidine clusters in double-stranded DNA. May also regulate alternative splicing of target genes during adipogenesis (By similarity); RNA binding motif containing | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.402 |
