node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BIRC6 | ENSG00000268434 | ENSP00000393596 | ENSP00000468837 | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] | Uncharacterized protein | 0.477 |
BIRC6 | ENSG00000272772 | ENSP00000393596 | ENSP00000430774 | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] | Uncharacterized protein; Belongs to the SKP1 family | 0.739 |
C20orf27 | ENSG00000268434 | ENSP00000217195 | ENSP00000468837 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Uncharacterized protein | 0.437 |
C20orf27 | PSME3 | ENSP00000217195 | ENSP00000293362 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] | 0.684 |
C20orf27 | RBFOX2 | ENSP00000217195 | ENSP00000413035 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Prevents binding of U2AF2 to the 3’-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha | 0.637 |
ENSG00000268434 | BIRC6 | ENSP00000468837 | ENSP00000393596 | Uncharacterized protein | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] | 0.477 |
ENSG00000268434 | C20orf27 | ENSP00000468837 | ENSP00000217195 | Uncharacterized protein | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.437 |
ENSG00000268434 | ENSG00000272772 | ENSP00000468837 | ENSP00000430774 | Uncharacterized protein | Uncharacterized protein; Belongs to the SKP1 family | 0.472 |
ENSG00000268434 | GRID2IP | ENSP00000468837 | ENSP00000397351 | Uncharacterized protein | Delphilin; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules; PDZ domain containing | 0.610 |
ENSG00000268434 | LONRF2 | ENSP00000468837 | ENSP00000377086 | Uncharacterized protein | LON peptidase N-terminal domain and ring finger 2 | 0.453 |
ENSG00000268434 | PSME3 | ENSP00000468837 | ENSP00000293362 | Uncharacterized protein | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] | 0.543 |
ENSG00000268434 | RBFOX2 | ENSP00000468837 | ENSP00000413035 | Uncharacterized protein | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5’-UGCAUGU-3’ elements. Prevents binding of U2AF2 to the 3’-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha | 0.488 |
ENSG00000268434 | USP12 | ENSP00000468837 | ENSP00000282344 | Uncharacterized protein | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability; Belongs to the peptidase C19 family. USP12/USP46 subfamily | 0.459 |
ENSG00000268434 | USP46 | ENSP00000468837 | ENSP00000407818 | Uncharacterized protein | Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Ubiquitin specific peptidases | 0.459 |
ENSG00000268434 | WDR48 | ENSP00000468837 | ENSP00000307491 | Uncharacterized protein | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In complex with USP12, acts [...] | 0.589 |
ENSG00000272772 | BIRC6 | ENSP00000430774 | ENSP00000393596 | Uncharacterized protein; Belongs to the SKP1 family | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] | 0.739 |
ENSG00000272772 | ENSG00000268434 | ENSP00000430774 | ENSP00000468837 | Uncharacterized protein; Belongs to the SKP1 family | Uncharacterized protein | 0.472 |
GRID2IP | ENSG00000268434 | ENSP00000397351 | ENSP00000468837 | Delphilin; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules; PDZ domain containing | Uncharacterized protein | 0.610 |
LONRF2 | ENSG00000268434 | ENSP00000377086 | ENSP00000468837 | LON peptidase N-terminal domain and ring finger 2 | Uncharacterized protein | 0.453 |
PSME3 | C20orf27 | ENSP00000293362 | ENSP00000217195 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 | 0.684 |