node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000266953 | H6PD | ENSP00000468690 | ENSP00000473348 | Uncharacterized protein | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | 0.784 |
ENSG00000266953 | PFKM | ENSP00000468690 | ENSP00000345771 | Uncharacterized protein | ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily | 0.735 |
ENSG00000266953 | PFKP | ENSP00000468690 | ENSP00000370517 | Uncharacterized protein | ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily | 0.735 |
ENSG00000266953 | PGK1 | ENSP00000468690 | ENSP00000362413 | Uncharacterized protein | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility | 0.810 |
ENSG00000266953 | PGK2 | ENSP00000468690 | ENSP00000305995 | Uncharacterized protein | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.810 |
ENSG00000266953 | PGM1 | ENSP00000468690 | ENSP00000360124 | Uncharacterized protein | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.807 |
ENSG00000266953 | PGM5 | ENSP00000468690 | ENSP00000379678 | Uncharacterized protein | Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity | 0.807 |
ENSG00000266953 | PKLR | ENSP00000468690 | ENSP00000339933 | Uncharacterized protein | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family | 0.775 |
ENSG00000266953 | PKM | ENSP00000468690 | ENSP00000320171 | Uncharacterized protein | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.775 |
ENSG00000266953 | TPI1 | ENSP00000468690 | ENSP00000229270 | Uncharacterized protein | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family | 0.915 |
H6PD | ENSG00000266953 | ENSP00000473348 | ENSP00000468690 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Uncharacterized protein | 0.784 |
H6PD | PFKM | ENSP00000473348 | ENSP00000345771 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily | 0.743 |
H6PD | PFKP | ENSP00000473348 | ENSP00000370517 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily | 0.569 |
H6PD | PGK1 | ENSP00000473348 | ENSP00000362413 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility | 0.690 |
H6PD | PGK2 | ENSP00000473348 | ENSP00000305995 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.593 |
H6PD | PGM1 | ENSP00000473348 | ENSP00000360124 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.959 |
H6PD | PGM5 | ENSP00000473348 | ENSP00000379678 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity | 0.797 |
H6PD | PKLR | ENSP00000473348 | ENSP00000339933 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family | 0.954 |
H6PD | PKM | ENSP00000473348 | ENSP00000320171 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation a [...] | 0.957 |
H6PD | TPI1 | ENSP00000473348 | ENSP00000229270 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family | 0.966 |