node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY2 | FAM26F | ENSP00000303570 | ENSP00000357594 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | 0.612 |
ANKMY2 | HEXB | ENSP00000303570 | ENSP00000261416 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.628 |
ANKMY2 | NMT1 | ENSP00000303570 | ENSP00000468424 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.619 |
ANKMY2 | PHF20L1 | ENSP00000303570 | ENSP00000378784 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | PHD finger protein 20 like 1 | 0.636 |
ANKMY2 | SPPL2A | ENSP00000303570 | ENSP00000261854 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] | 0.661 |
BID | NMT1 | ENSP00000318822 | ENSP00000468424 | BH3-interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2; BCL2 homology region 3 only | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.902 |
FAM26F | ANKMY2 | ENSP00000357594 | ENSP00000303570 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | 0.612 |
FAM26F | HEXB | ENSP00000357594 | ENSP00000261416 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.677 |
FAM26F | NMT1 | ENSP00000357594 | ENSP00000468424 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.663 |
FAM26F | PHF20L1 | ENSP00000357594 | ENSP00000378784 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | PHD finger protein 20 like 1 | 0.705 |
FAM26F | SPPL2A | ENSP00000357594 | ENSP00000261854 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] | 0.566 |
GNAT1 | NMT1 | ENSP00000232461 | ENSP00000468424 | Guanine nucleotide-binding protein G(t) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.912 |
HEXB | ANKMY2 | ENSP00000261416 | ENSP00000303570 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | 0.628 |
HEXB | FAM26F | ENSP00000261416 | ENSP00000357594 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel | 0.677 |
HEXB | NMT1 | ENSP00000261416 | ENSP00000468424 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.655 |
HEXB | PHF20L1 | ENSP00000261416 | ENSP00000378784 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | PHD finger protein 20 like 1 | 0.675 |
HEXB | SPPL2A | ENSP00000261416 | ENSP00000261854 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] | 0.596 |
LHX4-AS1 | NMT1 | ENSP00000356567 | ENSP00000468424 | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18-1-CoA, lower affinity for unsaturated C20-4-CoA, and very weak affinity for saturated C16-0- CoA. Does not bind fatty acids | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | 0.845 |
NMT1 | ANKMY2 | ENSP00000468424 | ENSP00000303570 | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing | 0.619 |
NMT1 | BID | ENSP00000468424 | ENSP00000318822 | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins | BH3-interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2; BCL2 homology region 3 only | 0.902 |