• Version:
  • 11.0 [archived version]
STRINGSTRING
DEPDC4 DEPDC4 TRIM28 TRIM28 HEATR4 HEATR4 TOX2 TOX2 ZNF461 ZNF461 TOX TOX TXNL4B TXNL4B CCDC134 CCDC134 NUDCD1 NUDCD1 FSIP1 FSIP1 JRKL JRKL
"ZNF461" - Zinc finger protein 461 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF461Zinc finger protein 461; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (563 aa)    
Predicted Functional Partners:
TOX2
TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system (506 aa)
       
 
  0.957
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
DEPDC4
DEP domain containing 4 (294 aa)
           
  0.642
CCDC134
Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling; Belongs to the CCDC134 family (229 aa)
           
  0.580
JRKL
Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family (524 aa)
       
 
  0.576
TOX
Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development (526 aa)
       
 
  0.563
HEATR4
HEAT repeat-containing protein 4; Armadillo-like helical domain containing (1026 aa)
           
  0.558
NUDCD1
NudC domain containing 1 (583 aa)
           
  0.557
TXNL4B
Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family (149 aa)
     
   
  0.552
FSIP1
Fibrous sheath interacting protein 1; Belongs to the FSIP1 family (581 aa)
           
  0.548
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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