node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX59 | ELL | ENSP00000330460 | ENSP00000262809 | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an [...] | 0.499 |
DDX59 | KIF14 | ENSP00000330460 | ENSP00000356319 | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | 0.529 |
DDX59 | LINGO3 | ENSP00000330460 | ENSP00000467753 | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | 0.783 |
DDX59 | OAZ1 | ENSP00000330460 | ENSP00000473381 | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular u [...] | 0.549 |
ELL | DDX59 | ENSP00000262809 | ENSP00000330460 | RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an [...] | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | 0.499 |
ELL | LINGO3 | ENSP00000262809 | ENSP00000467753 | RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an [...] | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | 0.496 |
KIF14 | DDX59 | ENSP00000356319 | ENSP00000330460 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | 0.529 |
KIF14 | LINGO3 | ENSP00000356319 | ENSP00000467753 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | 0.494 |
LINGO3 | DDX59 | ENSP00000467753 | ENSP00000330460 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily | 0.783 |
LINGO3 | ELL | ENSP00000467753 | ENSP00000262809 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an [...] | 0.496 |
LINGO3 | KIF14 | ENSP00000467753 | ENSP00000356319 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...] | 0.494 |
LINGO3 | LPHN1 | ENSP00000467753 | ENSP00000340688 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |
LINGO3 | LPHN2 | ENSP00000467753 | ENSP00000322270 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.685 |
LINGO3 | LPHN3 | ENSP00000467753 | ENSP00000422533 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.685 |
LINGO3 | LYPD5 | ENSP00000467753 | ENSP00000367185 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | LY6/PLAUR domain containing 5 | 0.471 |
LINGO3 | NRN1L | ENSP00000467753 | ENSP00000342411 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Neuritin-like protein; Neuritin 1 like | 0.541 |
LINGO3 | OAZ1 | ENSP00000467753 | ENSP00000473381 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular u [...] | 0.555 |
LINGO3 | RASGRP2 | ENSP00000467753 | ENSP00000338864 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway; Belongs to the RASGRP family | 0.433 |
LPHN1 | LINGO3 | ENSP00000340688 | ENSP00000467753 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | 0.685 |
LPHN2 | LINGO3 | ENSP00000322270 | ENSP00000467753 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 | 0.685 |