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STRINGSTRING
OR9A4 OR9A4 PILRB PILRB ALG1L2 ALG1L2 CCDC180 CCDC180 VKORC1L1 VKORC1L1 ANKRD62 ANKRD62 PVRIG PVRIG FAM86A FAM86A STAG3 STAG3 MTMR12 MTMR12 PDZK1 PDZK1
"ANKRD62" - Ankyrin repeat domain-containing protein 62 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ANKRD62Ankyrin repeat domain-containing protein 62; Ankyrin repeat domain containing (917 aa)    
Predicted Functional Partners:
PVRIG
Transmembrane protein PVRIG; Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding (326 aa)
            
  0.705
ALG1L2
Putative glycosyltransferase ALG1L2; Putative glycosyltransferase; Glycosyl transferases group 1 domain containing (215 aa)
        
 
  0.704
MTMR12
Myotubularin-related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily (747 aa)
            
  0.621
FAM86A
Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on ’Lys-525’ (330 aa)
            
  0.590
VKORC1L1
Vitamin K epoxide reductase complex subunit 1 like 1 (177 aa)
      
 
  0.589
CCDC180
Coiled-coil domain containing 180 (1701 aa)
            
  0.588
OR9A4
Olfactory receptor 9A4; Odorant receptor; Olfactory receptors, family 9 (314 aa)
            
  0.560
STAG3
Cohesin subunit SA-3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I; Armadillo-like helical domain containing (1226 aa)
      
 
  0.515
PILRB
Paired immunoglobin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface; V-set domain containing (227 aa)
            
  0.514
PDZK1
Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] (519 aa)
        
 
  0.491
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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