ZNF699 protein (human) - STRING database

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ZNF699

Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type (642 aa)

Predicted Functional Partners:

TRIM28

0.903

ANG

0.739

OR7G1

0.570

GABRA6

0.563

OR4D6

0.510

EIF2AK1

0.507

TMTC1

0.503

OR8B8

0.499

AGT

0.477

ADH6

0.470

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH6	GABRA6	ENSP00000378359	ENSP00000274545	Alcohol dehydrogenase 6	Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits	0.468
ADH6	ZNF699	ENSP00000378359	ENSP00000467723	Alcohol dehydrogenase 6	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.470
AGT	ZNF699	ENSP00000355627	ENSP00000467723	Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.477
ANG	ZNF699	ENSP00000336762	ENSP00000467723	Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo; Ribonuclease A family	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.739
EIF2AK1	ZNF699	ENSP00000199389	ENSP00000467723	Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...]	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.507
GABRA6	ADH6	ENSP00000274545	ENSP00000378359	Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits	Alcohol dehydrogenase 6	0.468
GABRA6	ZNF699	ENSP00000274545	ENSP00000467723	Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.563
OR4D6	ZNF699	ENSP00000300127	ENSP00000467723	Olfactory receptor 4D6; Odorant receptor; Olfactory receptors, family 4	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.510
OR7G1	ZNF699	ENSP00000444134	ENSP00000467723	Olfactory receptor 7G1; Odorant receptor; Olfactory receptors, family 7	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.570
OR8B8	ZNF699	ENSP00000330280	ENSP00000467723	Olfactory receptor 8B8; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 8	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.499
TMTC1	ZNF699	ENSP00000442046	ENSP00000467723	Transmembrane and tetratricopeptide repeat containing 1	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.503
TRIM28	ZNF699	ENSP00000253024	ENSP00000467723	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.903
ZNF699	ADH6	ENSP00000467723	ENSP00000378359	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Alcohol dehydrogenase 6	0.470
ZNF699	AGT	ENSP00000467723	ENSP00000355627	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands	0.477
ZNF699	ANG	ENSP00000467723	ENSP00000336762	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo; Ribonuclease A family	0.739
ZNF699	EIF2AK1	ENSP00000467723	ENSP00000199389	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...]	0.507
ZNF699	GABRA6	ENSP00000467723	ENSP00000274545	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Gamma-aminobutyric acid type A receptor subunits	0.563
ZNF699	OR4D6	ENSP00000467723	ENSP00000300127	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Olfactory receptor 4D6; Odorant receptor; Olfactory receptors, family 4	0.510
ZNF699	OR7G1	ENSP00000467723	ENSP00000444134	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Olfactory receptor 7G1; Odorant receptor; Olfactory receptors, family 7	0.570
ZNF699	OR8B8	ENSP00000467723	ENSP00000330280	Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Olfactory receptor 8B8; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 8	0.499

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