GPATCH8 protein (human) - STRING database

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GPATCH8

G-patch domain containing 8 (1502 aa)

Predicted Functional Partners:

EFTUD2

0.775

PRPF19

0.745

CLK3

0.699

CRNKL1

0.695

KMT2C

0.650

CWC25

0.627

CLK2

0.597

GPRIN1

0.597

DHX38

0.592

SRRM2

0.588

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLK2	CLK3	ENSP00000357345	ENSP00000378505	Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...]	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	0.589
CLK2	GPATCH8	ENSP00000357345	ENSP00000467556	Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...]	G-patch domain containing 8	0.597
CLK3	CLK2	ENSP00000378505	ENSP00000357345	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphory [...]	0.589
CLK3	GPATCH8	ENSP00000378505	ENSP00000467556	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	G-patch domain containing 8	0.699
CLK3	SRRM2	ENSP00000378505	ENSP00000301740	Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; CDC like kinases	Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family	0.664
CRNKL1	CWC25	ENSP00000366557	ENSP00000478070	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	0.981
CRNKL1	DHX38	ENSP00000366557	ENSP00000268482	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	0.995
CRNKL1	EFTUD2	ENSP00000366557	ENSP00000392094	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.999
CRNKL1	GPATCH8	ENSP00000366557	ENSP00000467556	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	G-patch domain containing 8	0.695
CRNKL1	PRPF19	ENSP00000366557	ENSP00000227524	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...]	0.999
CRNKL1	SRRM2	ENSP00000366557	ENSP00000301740	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family	0.994
CWC25	CRNKL1	ENSP00000478070	ENSP00000366557	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	0.981
CWC25	DHX38	ENSP00000478070	ENSP00000268482	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	0.998
CWC25	EFTUD2	ENSP00000478070	ENSP00000392094	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.994
CWC25	GPATCH8	ENSP00000478070	ENSP00000467556	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	G-patch domain containing 8	0.627
CWC25	PRPF19	ENSP00000478070	ENSP00000227524	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...]	0.988
CWC25	SRRM2	ENSP00000478070	ENSP00000301740	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family	0.986
DHX38	CRNKL1	ENSP00000268482	ENSP00000366557	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family	0.995
DHX38	CWC25	ENSP00000268482	ENSP00000478070	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex	0.998
DHX38	EFTUD2	ENSP00000268482	ENSP00000392094	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.996

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