node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMMECR1L | C10orf76 | ENSP00000272647 | ENSP00000359050 | AMMECR1-like protein; AMMECR1 like | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | 0.530 |
AMMECR1L | CC2D1B | ENSP00000272647 | ENSP00000360642 | AMMECR1-like protein; AMMECR1 like | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | 0.601 |
AMMECR1L | FCF1 | ENSP00000272647 | ENSP00000344393 | AMMECR1-like protein; AMMECR1 like | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | 0.531 |
AMMECR1L | GPATCH3 | ENSP00000272647 | ENSP00000354645 | AMMECR1-like protein; AMMECR1 like | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6; G [...] | 0.599 |
AMMECR1L | TMUB2 | ENSP00000272647 | ENSP00000466971 | AMMECR1-like protein; AMMECR1 like | Transmembrane and ubiquitin like domain containing 2 | 0.538 |
C10orf76 | AMMECR1L | ENSP00000359050 | ENSP00000272647 | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | AMMECR1-like protein; AMMECR1 like | 0.530 |
C10orf76 | CC2D1B | ENSP00000359050 | ENSP00000360642 | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | 0.547 |
C10orf76 | FCF1 | ENSP00000359050 | ENSP00000344393 | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | 0.516 |
C10orf76 | GPATCH3 | ENSP00000359050 | ENSP00000354645 | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6; G [...] | 0.554 |
C10orf76 | TMUB2 | ENSP00000359050 | ENSP00000466971 | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | Transmembrane and ubiquitin like domain containing 2 | 0.528 |
C15orf39 | DENND3 | ENSP00000353854 | ENSP00000262585 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | 0.528 |
C15orf39 | TMUB2 | ENSP00000353854 | ENSP00000466971 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39 | Transmembrane and ubiquitin like domain containing 2 | 0.519 |
CC2D1B | AMMECR1L | ENSP00000360642 | ENSP00000272647 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | AMMECR1-like protein; AMMECR1 like | 0.601 |
CC2D1B | C10orf76 | ENSP00000360642 | ENSP00000359050 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 | 0.547 |
CC2D1B | FCF1 | ENSP00000360642 | ENSP00000344393 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | 0.526 |
CC2D1B | GPATCH3 | ENSP00000360642 | ENSP00000354645 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6; G [...] | 0.579 |
CC2D1B | TMUB2 | ENSP00000360642 | ENSP00000466971 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing | Transmembrane and ubiquitin like domain containing 2 | 0.532 |
DENND3 | C15orf39 | ENSP00000262585 | ENSP00000353854 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39 | 0.528 |
DENND3 | TMUB2 | ENSP00000262585 | ENSP00000466971 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] | Transmembrane and ubiquitin like domain containing 2 | 0.519 |
FCF1 | AMMECR1L | ENSP00000344393 | ENSP00000272647 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | AMMECR1-like protein; AMMECR1 like | 0.531 |