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  • 11.0 [archived version]
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RSAD1 RSAD1 THSD7A THSD7A C15orf39 C15orf39 TMEM53 TMEM53 TMUB2 TMUB2 DENND3 DENND3 CC2D1B CC2D1B AMMECR1L AMMECR1L FCF1 FCF1 GPATCH3 GPATCH3 C10orf76 C10orf76
"TMUB2" - Transmembrane and ubiquitin like domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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TMUB2Transmembrane and ubiquitin like domain containing 2 (321 aa)    
Predicted Functional Partners:
THSD7A
Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism (1657 aa)
       
      0.802
TMEM53
Transmembrane protein 53; Belongs to the TMEM53 family (277 aa)
     
   
  0.597
GPATCH3
G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6; G [...] (525 aa)
           
  0.557
AMMECR1L
AMMECR1-like protein; AMMECR1 like (310 aa)
           
  0.538
CC2D1B
Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 domain containing (858 aa)
           
  0.532
C10orf76
UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 (689 aa)
           
  0.528
RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be involved in porphyrin cofactor biosynthesis; Belongs to the anaerobic coproporphyrinogen-III oxidase family (442 aa)
           
  0.525
DENND3
DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the deg [...] (1198 aa)
           
  0.519
C15orf39
Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39 (1047 aa)
           
  0.519
FCF1
rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (198 aa)
           
  0.504
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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