• Version:
  • 11.0 [archived version]
STRINGSTRING
NSA2 NSA2 SP140L SP140L GPR15 GPR15 SPON1 SPON1 ZNF266 ZNF266 MRPL43 MRPL43 ZNF321P ZNF321P TRIM28 TRIM28 ZNF69 ZNF69 TMEM161A TMEM161A MANEAL MANEAL
"ZNF266" - Zinc finger protein 266 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF266Zinc finger protein 266; May be involved in transcriptional regulation; Zinc fingers C2H2-type (549 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
SPON1
Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell (807 aa)
           
  0.622
ZNF321P
Putative protein ZNF321; Zinc finger protein 321, pseudogene (233 aa)
           
  0.570
SP140L
SP140 nuclear body protein like; Bromodomain containing (580 aa)
     
 
  0.493
NSA2
Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) (260 aa)
           
  0.484
ZNF69
Zinc finger protein 69; Zinc fingers C2H2-type (149 aa)
           
  0.473
TMEM161A
Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis; Belongs to the TMEM161 family (479 aa)
           
  0.473
MANEAL
Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family (457 aa)
           
  0.440
GPR15
G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans (360 aa)
           
  0.419
MRPL43
Mitochondrial ribosomal protein L43 (235 aa)
       
 
  0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]