node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BOP1 | ENSG00000267157 | ENSP00000455106 | ENSP00000466514 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Uncharacterized protein | 0.664 |
BOP1 | ENSG00000271786 | ENSP00000455106 | ENSP00000476221 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Uncharacterized protein | 0.915 |
BOP1 | NOP2 | ENSP00000455106 | ENSP00000371858 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family | 0.997 |
BOP1 | PUS1 | ENSP00000455106 | ENSP00000365837 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity); Belongs to the tRNA pseudouridine synthase TruA family | 0.518 |
BOP1 | PWP1 | ENSP00000455106 | ENSP00000387365 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Periodic tryptophan protein 1 homolog; May play an important role in cell growth and/or transcription; Belongs to the WD repeat PWP1 family | 0.922 |
BOP1 | RRP9 | ENSP00000455106 | ENSP00000232888 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA; Belongs to the WD repeat RRP9 family | 0.990 |
BOP1 | WDR12 | ENSP00000455106 | ENSP00000261015 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing | 0.999 |
BOP1 | WDR36 | ENSP00000455106 | ENSP00000423067 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex | 0.993 |
DUS2 | ENSG00000267157 | ENSP00000455229 | ENSP00000466514 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR | Uncharacterized protein | 0.509 |
DUS2 | PUS1 | ENSP00000455229 | ENSP00000365837 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR | tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity); Belongs to the tRNA pseudouridine synthase TruA family | 0.637 |
ENSG00000267157 | BOP1 | ENSP00000466514 | ENSP00000455106 | Uncharacterized protein | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | 0.664 |
ENSG00000267157 | DUS2 | ENSP00000466514 | ENSP00000455229 | Uncharacterized protein | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR | 0.509 |
ENSG00000267157 | ENSG00000271786 | ENSP00000466514 | ENSP00000476221 | Uncharacterized protein | Uncharacterized protein | 0.427 |
ENSG00000267157 | H6PD | ENSP00000466514 | ENSP00000473348 | Uncharacterized protein | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6- phosphogluconolactonase subfamily | 0.456 |
ENSG00000267157 | NOP2 | ENSP00000466514 | ENSP00000371858 | Uncharacterized protein | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family | 0.427 |
ENSG00000267157 | PUS1 | ENSP00000466514 | ENSP00000365837 | Uncharacterized protein | tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity); Belongs to the tRNA pseudouridine synthase TruA family | 0.435 |
ENSG00000267157 | PWP1 | ENSP00000466514 | ENSP00000387365 | Uncharacterized protein | Periodic tryptophan protein 1 homolog; May play an important role in cell growth and/or transcription; Belongs to the WD repeat PWP1 family | 0.428 |
ENSG00000267157 | RRP9 | ENSP00000466514 | ENSP00000232888 | Uncharacterized protein | U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA; Belongs to the WD repeat RRP9 family | 0.446 |
ENSG00000267157 | WDR12 | ENSP00000466514 | ENSP00000261015 | Uncharacterized protein | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing | 0.630 |
ENSG00000267157 | WDR36 | ENSP00000466514 | ENSP00000423067 | Uncharacterized protein | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex | 0.461 |