NLRP11 protein (human) - STRING database

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NLRP11

NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family (1033 aa)

Predicted Functional Partners:

LPHN3

0.683

LPHN1

0.683

LPHN2

0.683

OR6K2

0.557

ZNF563

0.545

MEFV

0.543

OR2T6

0.515

OR9G4

0.491

OR52M1

0.473

OR4K15

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LPHN1	NLRP11	ENSP00000340688	ENSP00000466285	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.683
LPHN2	NLRP11	ENSP00000322270	ENSP00000466285	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.683
LPHN3	NLRP11	ENSP00000422533	ENSP00000466285	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.683
MEFV	NLRP11	ENSP00000219596	ENSP00000466285	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.543
NLRP11	LPHN1	ENSP00000466285	ENSP00000340688	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	0.683
NLRP11	LPHN2	ENSP00000466285	ENSP00000322270	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	0.683
NLRP11	LPHN3	ENSP00000466285	ENSP00000422533	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	0.683
NLRP11	MEFV	ENSP00000466285	ENSP00000219596	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	0.543
NLRP11	OR2T6	ENSP00000466285	ENSP00000347965	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Olfactory receptor 2T6; Odorant receptor; Olfactory receptors, family 2	0.515
NLRP11	OR4K15	ENSP00000466285	ENSP00000304077	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Olfactory receptor 4K15; Odorant receptor; Olfactory receptors, family 4	0.473
NLRP11	OR52M1	ENSP00000466285	ENSP00000353343	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Olfactory receptor 52M1; Odorant receptor; Olfactory receptors, family 52	0.473
NLRP11	OR6K2	ENSP00000466285	ENSP00000352626	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Olfactory receptor 6K2; Odorant receptor; Olfactory receptors, family 6	0.557
NLRP11	OR9G4	ENSP00000466285	ENSP00000307515	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Olfactory receptor 9G4; Odorant receptor; Olfactory receptors, family 9	0.491
NLRP11	ZNF563	ENSP00000466285	ENSP00000293725	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	Zinc finger protein 563; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.545
OR2T6	NLRP11	ENSP00000347965	ENSP00000466285	Olfactory receptor 2T6; Odorant receptor; Olfactory receptors, family 2	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.515
OR4K15	NLRP11	ENSP00000304077	ENSP00000466285	Olfactory receptor 4K15; Odorant receptor; Olfactory receptors, family 4	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.473
OR52M1	NLRP11	ENSP00000353343	ENSP00000466285	Olfactory receptor 52M1; Odorant receptor; Olfactory receptors, family 52	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.473
OR6K2	NLRP11	ENSP00000352626	ENSP00000466285	Olfactory receptor 6K2; Odorant receptor; Olfactory receptors, family 6	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.557
OR9G4	NLRP11	ENSP00000307515	ENSP00000466285	Olfactory receptor 9G4; Odorant receptor; Olfactory receptors, family 9	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.491
ZNF563	NLRP11	ENSP00000293725	ENSP00000466285	Zinc finger protein 563; May be involved in transcriptional regulation; Zinc fingers C2H2-type	NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family	0.545

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