| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM150A | FAM78A | ENSP00000351345 | ENSP00000361345 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | 0.591 |
| FAM150A | KHDRBS2 | ENSP00000351345 | ENSP00000281156 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin [...] | 0.447 |
| FAM150A | PCDHAC1 | ENSP00000351345 | ENSP00000253807 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.587 |
| FAM150A | PRAC1 | ENSP00000351345 | ENSP00000290294 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | PRAC1 small nuclear protein | 0.475 |
| FAM150A | RIMS4 | ENSP00000351345 | ENSP00000439287 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis | 0.557 |
| FAM150A | SLC13A5 | ENSP00000351345 | ENSP00000406220 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily | 0.422 |
| FAM150A | ZNF540 | ENSP00000351345 | ENSP00000466274 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | Zinc finger protein 540; May act as a transcriptional repressor; Zinc fingers C2H2-type | 0.630 |
| FAM78A | FAM150A | ENSP00000361345 | ENSP00000351345 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.591 |
| FAM78A | GRM6 | ENSP00000361345 | ENSP00000231188 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | 0.445 |
| FAM78A | KHDRBS2 | ENSP00000361345 | ENSP00000281156 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin [...] | 0.539 |
| FAM78A | PCDHAC1 | ENSP00000361345 | ENSP00000253807 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.669 |
| FAM78A | PRAC1 | ENSP00000361345 | ENSP00000290294 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | PRAC1 small nuclear protein | 0.557 |
| FAM78A | RIMS4 | ENSP00000361345 | ENSP00000439287 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis | 0.655 |
| FAM78A | SLC13A5 | ENSP00000361345 | ENSP00000406220 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily | 0.517 |
| FAM78A | ZNF540 | ENSP00000361345 | ENSP00000466274 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | Zinc finger protein 540; May act as a transcriptional repressor; Zinc fingers C2H2-type | 0.670 |
| GRM6 | FAM78A | ENSP00000231188 | ENSP00000361345 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family | 0.445 |
| GRM6 | PCDHAC1 | ENSP00000231188 | ENSP00000253807 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.461 |
| GRM6 | RIMS4 | ENSP00000231188 | ENSP00000439287 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis | 0.444 |
| GRM6 | ZNF540 | ENSP00000231188 | ENSP00000466274 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision; Glutamate metabotropic receptors | Zinc finger protein 540; May act as a transcriptional repressor; Zinc fingers C2H2-type | 0.475 |
| KHDRBS2 | FAM150A | ENSP00000281156 | ENSP00000351345 | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin [...] | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly | 0.447 |
