| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DBNDD1 | PDCD5 | ENSP00000457625 | ENSP00000466214 | Dysbindin domain containing 1 | Programmed cell death protein 5; May function in the process of apoptosis | 0.710 |
| KAT5 | PDCD5 | ENSP00000340330 | ENSP00000466214 | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | Programmed cell death protein 5; May function in the process of apoptosis | 0.789 |
| KAT5 | TP53 | ENSP00000340330 | ENSP00000269305 | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.990 |
| OTUD5 | PDCD5 | ENSP00000156084 | ENSP00000466214 | OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains. Can also cleave ’Lys-11’- linked ubiquitin chains (in vitro) | Programmed cell death protein 5; May function in the process of apoptosis | 0.641 |
| OTUD5 | TP53 | ENSP00000156084 | ENSP00000269305 | OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains. Can also cleave ’Lys-11’- linked ubiquitin chains (in vitro) | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.718 |
| OTUD5 | YAF2 | ENSP00000156084 | ENSP00000328004 | OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains. Can also cleave ’Lys-11’- linked ubiquitin chains (in vitro) | YY1 associated factor 2, isoform CRA_d; Zinc fingers RANBP2-type | 0.424 |
| PBDC1 | PDCD5 | ENSP00000362456 | ENSP00000466214 | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family | Programmed cell death protein 5; May function in the process of apoptosis | 0.686 |
| PBDC1 | SNRPG | ENSP00000362456 | ENSP00000272348 | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.657 |
| PBDC1 | VBP1 | ENSP00000362456 | ENSP00000286428 | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | 0.514 |
| PDCD5 | DBNDD1 | ENSP00000466214 | ENSP00000457625 | Programmed cell death protein 5; May function in the process of apoptosis | Dysbindin domain containing 1 | 0.710 |
| PDCD5 | KAT5 | ENSP00000466214 | ENSP00000340330 | Programmed cell death protein 5; May function in the process of apoptosis | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] | 0.789 |
| PDCD5 | OTUD5 | ENSP00000466214 | ENSP00000156084 | Programmed cell death protein 5; May function in the process of apoptosis | OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains. Can also cleave ’Lys-11’- linked ubiquitin chains (in vitro) | 0.641 |
| PDCD5 | PBDC1 | ENSP00000466214 | ENSP00000362456 | Programmed cell death protein 5; May function in the process of apoptosis | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family | 0.686 |
| PDCD5 | PFDN5 | ENSP00000466214 | ENSP00000447942 | Programmed cell death protein 5; May function in the process of apoptosis | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family | 0.913 |
| PDCD5 | PFDN6 | ENSP00000466214 | ENSP00000378563 | Programmed cell death protein 5; May function in the process of apoptosis | Prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | 0.752 |
| PDCD5 | SNRPG | ENSP00000466214 | ENSP00000272348 | Programmed cell death protein 5; May function in the process of apoptosis | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.701 |
| PDCD5 | TP53 | ENSP00000466214 | ENSP00000269305 | Programmed cell death protein 5; May function in the process of apoptosis | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.812 |
| PDCD5 | VBP1 | ENSP00000466214 | ENSP00000286428 | Programmed cell death protein 5; May function in the process of apoptosis | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Prefoldin subunits | 0.741 |
| PDCD5 | YAF2 | ENSP00000466214 | ENSP00000328004 | Programmed cell death protein 5; May function in the process of apoptosis | YY1 associated factor 2, isoform CRA_d; Zinc fingers RANBP2-type | 0.793 |
| PFDN5 | PDCD5 | ENSP00000447942 | ENSP00000466214 | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC; Belongs to the prefoldin subunit alpha family | Programmed cell death protein 5; May function in the process of apoptosis | 0.913 |
