| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKLE1 | ZNF404 | ENSP00000377971 | ENSP00000466051 | Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair; Ankyrin repeat domain containing | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.404 |
| COCH | OTOA | ENSP00000379862 | ENSP00000373610 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family | 0.468 |
| COCH | ZNF404 | ENSP00000379862 | ENSP00000466051 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.424 |
| CTSW | ZNF404 | ENSP00000311300 | ENSP00000466051 | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Cathepsins | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.494 |
| CUL7 | PRKDC | ENSP00000438788 | ENSP00000313420 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...] | 0.454 |
| CUL7 | RNF182 | ENSP00000438788 | ENSP00000420465 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway; Ring finger proteins | 0.900 |
| CUL7 | ZNF404 | ENSP00000438788 | ENSP00000466051 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.637 |
| LIMS3 | ZNF404 | ENSP00000405165 | ENSP00000466051 | LIM and senescent cell antigen-like-containing domain protein 3; LIM zinc finger domain containing 3 | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.433 |
| LIMS3L | RNF182 | ENSP00000404432 | ENSP00000420465 | LIM and senescent cell antigen-like domains 3-like | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway; Ring finger proteins | 0.424 |
| LIMS3L | ZNF404 | ENSP00000404432 | ENSP00000466051 | LIM and senescent cell antigen-like domains 3-like | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.506 |
| OTOA | COCH | ENSP00000373610 | ENSP00000379862 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.468 |
| OTOA | ZNF404 | ENSP00000373610 | ENSP00000466051 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.434 |
| PRKDC | CUL7 | ENSP00000313420 | ENSP00000438788 | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...] | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.454 |
| PRKDC | ZNF404 | ENSP00000313420 | ENSP00000466051 | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...] | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.510 |
| RNF182 | CUL7 | ENSP00000420465 | ENSP00000438788 | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway; Ring finger proteins | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.900 |
| RNF182 | LIMS3L | ENSP00000420465 | ENSP00000404432 | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway; Ring finger proteins | LIM and senescent cell antigen-like domains 3-like | 0.424 |
| RNF182 | ZNF404 | ENSP00000420465 | ENSP00000466051 | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway; Ring finger proteins | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.461 |
| STXBP4 | ZNF404 | ENSP00000365530 | ENSP00000466051 | Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity); PDZ domain containing | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.491 |
| ZNF404 | ANKLE1 | ENSP00000466051 | ENSP00000377971 | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair; Ankyrin repeat domain containing | 0.404 |
| ZNF404 | COCH | ENSP00000466051 | ENSP00000379862 | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.424 |
