| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHDH | ENSG00000258728 | ENSP00000221403 | ENSP00000451792 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Uncharacterized protein | 0.515 |
| DHDH | GALE | ENSP00000221403 | ENSP00000483375 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | 0.611 |
| DHDH | GALK1 | ENSP00000221403 | ENSP00000465930 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily | 0.750 |
| DHDH | GALM | ENSP00000221403 | ENSP00000272252 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.510 |
| DHDH | GALT | ENSP00000221403 | ENSP00000368119 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism | 0.524 |
| ENSG00000258728 | DHDH | ENSP00000451792 | ENSP00000221403 | Uncharacterized protein | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | 0.515 |
| ENSG00000258728 | GALE | ENSP00000451792 | ENSP00000483375 | Uncharacterized protein | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | 0.913 |
| ENSG00000258728 | GALK1 | ENSP00000451792 | ENSP00000465930 | Uncharacterized protein | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily | 0.853 |
| ENSG00000258728 | GALM | ENSP00000451792 | ENSP00000272252 | Uncharacterized protein | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.632 |
| ENSG00000258728 | UGDH | ENSP00000451792 | ENSP00000319501 | Uncharacterized protein | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate | 0.462 |
| ENSG00000258728 | UGP2 | ENSP00000451792 | ENSP00000338703 | Uncharacterized protein | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family | 0.682 |
| GALE | DHDH | ENSP00000483375 | ENSP00000221403 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | 0.611 |
| GALE | ENSG00000258728 | ENSP00000483375 | ENSP00000451792 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Uncharacterized protein | 0.913 |
| GALE | GALK1 | ENSP00000483375 | ENSP00000465930 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily | 0.988 |
| GALE | GALM | ENSP00000483375 | ENSP00000272252 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.962 |
| GALE | GALT | ENSP00000483375 | ENSP00000368119 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism | 0.999 |
| GALE | SLC35A2 | ENSP00000483375 | ENSP00000416002 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily | 0.508 |
| GALE | UGDH | ENSP00000483375 | ENSP00000319501 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate | 0.987 |
| GALE | UGP2 | ENSP00000483375 | ENSP00000338703 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions- the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconver [...] | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family | 0.989 |
| GALK1 | DHDH | ENSP00000465930 | ENSP00000221403 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family | 0.750 |
