node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUD31 | CCDC130 | ENSP00000386023 | ENSP00000465776 | Protein BUD31 homolog; Spliceosomal Bact complex | Coiled-coil domain containing 130; Belongs to the CWC16 family | 0.850 |
BUD31 | CDC40 | ENSP00000386023 | ENSP00000357928 | Protein BUD31 homolog; Spliceosomal Bact complex | Pre-mRNA-processing factor 17; Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing; Spliceosomal Bact complex | 0.999 |
BUD31 | CDC5L | ENSP00000386023 | ENSP00000360532 | Protein BUD31 homolog; Spliceosomal Bact complex | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | 0.998 |
BUD31 | CWC15 | ENSP00000386023 | ENSP00000475615 | Protein BUD31 homolog; Spliceosomal Bact complex | Spliceosome-associated protein CWC15 homolog; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.998 |
BUD31 | CWC22 | ENSP00000386023 | ENSP00000387006 | Protein BUD31 homolog; Spliceosomal Bact complex | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family | 0.998 |
BUD31 | EFTUD2 | ENSP00000386023 | ENSP00000392094 | Protein BUD31 homolog; Spliceosomal Bact complex | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.999 |
BUD31 | PRPF19 | ENSP00000386023 | ENSP00000227524 | Protein BUD31 homolog; Spliceosomal Bact complex | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | 0.999 |
BUD31 | WDR25 | ENSP00000386023 | ENSP00000334148 | Protein BUD31 homolog; Spliceosomal Bact complex | WD repeat-containing protein 25; WD repeat domain containing | 0.854 |
CCDC130 | BUD31 | ENSP00000465776 | ENSP00000386023 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Protein BUD31 homolog; Spliceosomal Bact complex | 0.850 |
CCDC130 | CDC40 | ENSP00000465776 | ENSP00000357928 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Pre-mRNA-processing factor 17; Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing; Spliceosomal Bact complex | 0.828 |
CCDC130 | CDC5L | ENSP00000465776 | ENSP00000360532 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | 0.832 |
CCDC130 | CWC15 | ENSP00000465776 | ENSP00000475615 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Spliceosome-associated protein CWC15 homolog; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.743 |
CCDC130 | CWC22 | ENSP00000465776 | ENSP00000387006 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family | 0.814 |
CCDC130 | EFTUD2 | ENSP00000465776 | ENSP00000392094 | Coiled-coil domain containing 130; Belongs to the CWC16 family | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.823 |
CCDC130 | JUP | ENSP00000465776 | ENSP00000377508 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhes [...] | 0.766 |
CCDC130 | KDM8 | ENSP00000465776 | ENSP00000398410 | Coiled-coil domain containing 130; Belongs to the CWC16 family | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | 0.823 |
CCDC130 | PRPF19 | ENSP00000465776 | ENSP00000227524 | Coiled-coil domain containing 130; Belongs to the CWC16 family | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates ’Lys-63’-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruite [...] | 0.786 |
CCDC130 | WDR25 | ENSP00000465776 | ENSP00000334148 | Coiled-coil domain containing 130; Belongs to the CWC16 family | WD repeat-containing protein 25; WD repeat domain containing | 0.772 |
CDC40 | BUD31 | ENSP00000357928 | ENSP00000386023 | Pre-mRNA-processing factor 17; Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing; Spliceosomal Bact complex | Protein BUD31 homolog; Spliceosomal Bact complex | 0.999 |
CDC40 | CCDC130 | ENSP00000357928 | ENSP00000465776 | Pre-mRNA-processing factor 17; Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing; Spliceosomal Bact complex | Coiled-coil domain containing 130; Belongs to the CWC16 family | 0.828 |