| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC106 | HABP4 | ENSP00000465757 | ENSP00000364398 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step | 0.632 |
| CCDC106 | HMBOX1 | ENSP00000465757 | ENSP00000380516 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes | 0.497 |
| CCDC106 | RNF150 | ENSP00000465757 | ENSP00000425840 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Ring finger protein 150 | 0.536 |
| CCDC106 | SNX15 | ENSP00000465757 | ENSP00000366452 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN; Sorting nexins | 0.630 |
| CCDC106 | TAF3 | ENSP00000465757 | ENSP00000340271 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process; Armadillo-like helical domain containing | 0.495 |
| CCDC106 | TMEM100 | ENSP00000465757 | ENSP00000465638 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open p [...] | 0.524 |
| CCDC106 | TMEM63C | ENSP00000465757 | ENSP00000298351 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel | 0.566 |
| CCDC106 | TP53 | ENSP00000465757 | ENSP00000269305 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.917 |
| CCDC106 | VWA5A | ENSP00000465757 | ENSP00000407726 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis | 0.543 |
| CCDC106 | ZBTB48 | ENSP00000465757 | ENSP00000366902 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | Telomere zinc finger-associated protein; Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5’-TTAGGG-3’ repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements i [...] | 0.491 |
| HABP4 | CCDC106 | ENSP00000364398 | ENSP00000465757 | Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress (By similarity). Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | 0.632 |
| HMBOX1 | CCDC106 | ENSP00000380516 | ENSP00000465757 | Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | 0.497 |
| HMBOX1 | RNF150 | ENSP00000380516 | ENSP00000425840 | Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes | Ring finger protein 150 | 0.431 |
| HMBOX1 | ZBTB48 | ENSP00000380516 | ENSP00000366902 | Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes | Telomere zinc finger-associated protein; Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5’-TTAGGG-3’ repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Regulates expression the J and/or S elements i [...] | 0.588 |
| RNF150 | CCDC106 | ENSP00000425840 | ENSP00000465757 | Ring finger protein 150 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | 0.536 |
| RNF150 | HMBOX1 | ENSP00000425840 | ENSP00000380516 | Ring finger protein 150 | Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes | 0.431 |
| RNF150 | SNX15 | ENSP00000425840 | ENSP00000366452 | Ring finger protein 150 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN; Sorting nexins | 0.596 |
| RNF150 | TMEM100 | ENSP00000425840 | ENSP00000465638 | Ring finger protein 150 | Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open p [...] | 0.470 |
| RNF150 | TMEM63C | ENSP00000425840 | ENSP00000298351 | Ring finger protein 150 | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel | 0.486 |
| SNX15 | CCDC106 | ENSP00000366452 | ENSP00000465757 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN; Sorting nexins | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity | 0.630 |
