| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C11orf80 | FAM122C | ENSP00000354227 | ENSP00000359820 | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | Protein FAM122C; Family with sequence similarity 122C | 0.642 |
| C11orf80 | ZNF850 | ENSP00000354227 | ENSP00000464976 | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.400 |
| CYP20A1 | ZNF850 | ENSP00000348380 | ENSP00000464976 | Cytochrome P450 family 20 subfamily A member 1 | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.520 |
| FAM122C | C11orf80 | ENSP00000359820 | ENSP00000354227 | Protein FAM122C; Family with sequence similarity 122C | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles | 0.642 |
| FAM122C | ZNF850 | ENSP00000359820 | ENSP00000464976 | Protein FAM122C; Family with sequence similarity 122C | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.475 |
| GNL3L | NOL9 | ENSP00000338573 | ENSP00000366934 | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | 0.403 |
| GNL3L | SLC35E2 | ENSP00000338573 | ENSP00000246421 | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | Solute carrier family 35 member E2; Putative transporter; Solute carriers | 0.400 |
| GNL3L | ZNF850 | ENSP00000338573 | ENSP00000464976 | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.526 |
| NOL9 | GNL3L | ENSP00000366934 | ENSP00000338573 | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | 0.403 |
| NOL9 | SLC35E2 | ENSP00000366934 | ENSP00000246421 | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | Solute carrier family 35 member E2; Putative transporter; Solute carriers | 0.411 |
| NOL9 | SLC35E2B | ENSP00000366934 | ENSP00000481694 | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | Solute carrier family 35 member E2B; Putative transporter; Solute carriers | 0.411 |
| NOL9 | ZNF850 | ENSP00000366934 | ENSP00000464976 | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.551 |
| PLCXD1 | ZNF850 | ENSP00000371073 | ENSP00000464976 | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.490 |
| PPM1K | ZNF850 | ENSP00000477341 | ENSP00000464976 | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.451 |
| RBMS2 | ZNF850 | ENSP00000262031 | ENSP00000464976 | RNA-binding motif, single-stranded-interacting protein 2; RNA binding motif single stranded interacting protein 2 | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.440 |
| SLC35E2 | GNL3L | ENSP00000246421 | ENSP00000338573 | Solute carrier family 35 member E2; Putative transporter; Solute carriers | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] | 0.400 |
| SLC35E2 | NOL9 | ENSP00000246421 | ENSP00000366934 | Solute carrier family 35 member E2; Putative transporter; Solute carriers | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | 0.411 |
| SLC35E2 | ZNF850 | ENSP00000246421 | ENSP00000464976 | Solute carrier family 35 member E2; Putative transporter; Solute carriers | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.557 |
| SLC35E2B | NOL9 | ENSP00000481694 | ENSP00000366934 | Solute carrier family 35 member E2B; Putative transporter; Solute carriers | Polynucleotide 5’-hydroxyl-kinase NOL9; Polynucleotide 5’-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5’-kinase activities. Probably binds RNA; Belongs to the Clp1 family. NOL9/GRC3 subfamily | 0.411 |
| SLC35E2B | ZNF850 | ENSP00000481694 | ENSP00000464976 | Solute carrier family 35 member E2B; Putative transporter; Solute carriers | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.557 |
