• Version:
  • 11.0 [archived version]
STRINGSTRING
TRIM28 TRIM28 ZNF285 ZNF285 TRAPPC6B TRAPPC6B DRG1 DRG1 OR5M3 OR5M3 C1orf189 C1orf189 C10orf62 C10orf62 PASK PASK XAGE5 XAGE5 ARMCX6 ARMCX6 FAM129C FAM129C
"ZNF285" - Zinc finger protein 285 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF285Zinc finger protein 285; May be involved in transcriptional regulation; Zinc fingers C2H2-type (597 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
C10orf62
Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62 (223 aa)
           
  0.678
C1orf189
Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189 (101 aa)
           
  0.677
OR5M3
Olfactory receptor 5M3; Odorant receptor; Olfactory receptors, family 5 (307 aa)
           
  0.669
XAGE5
X antigen family member 5; Belongs to the GAGE family (108 aa)
           
  0.652
ARMCX6
Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing (300 aa)
           
  0.644
PASK
PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis- regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in [...] (1330 aa)
     
 
  0.621
TRAPPC6B
Trafficking protein particle complex subunit 6B; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Trafficking protein particle complex (158 aa)
           
  0.572
FAM129C
Niban-like protein 2; Family with sequence similarity 129 member C; Belongs to the Niban family (697 aa)
           
  0.557
DRG1
Developmentally-regulated GTP-binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest (367 aa)
           
  0.556
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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