| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGBL3 | C18orf63 | ENSP00000388275 | ENSP00000464330 | Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy- terminus of tubulin; M14 carboxypeptidases | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | 0.511 |
| AGBL3 | LRGUK | ENSP00000388275 | ENSP00000285928 | Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy- terminus of tubulin; M14 carboxypeptidases | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis; Cilia and flagella associated | 0.568 |
| C18orf63 | AGBL3 | ENSP00000464330 | ENSP00000388275 | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy- terminus of tubulin; M14 carboxypeptidases | 0.511 |
| C18orf63 | CHCHD3 | ENSP00000464330 | ENSP00000262570 | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | 0.472 |
| C18orf63 | LRGUK | ENSP00000464330 | ENSP00000285928 | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis; Cilia and flagella associated | 0.633 |
| C18orf63 | MED29 | ENSP00000464330 | ENSP00000314343 | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.404 |
| C18orf63 | SLFN12L | ENSP00000464330 | ENSP00000437635 | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | Schlafen family member 12 like; Belongs to the Schlafen family | 0.497 |
| CHCHD3 | C18orf63 | ENSP00000262570 | ENSP00000464330 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | 0.472 |
| CHCHD3 | LRGUK | ENSP00000262570 | ENSP00000285928 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis; Cilia and flagella associated | 0.461 |
| LRGUK | AGBL3 | ENSP00000285928 | ENSP00000388275 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis; Cilia and flagella associated | Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy- terminus of tubulin; M14 carboxypeptidases | 0.568 |
| LRGUK | C18orf63 | ENSP00000285928 | ENSP00000464330 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis; Cilia and flagella associated | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | 0.633 |
| LRGUK | CHCHD3 | ENSP00000285928 | ENSP00000262570 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis; Cilia and flagella associated | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | 0.461 |
| MED29 | C18orf63 | ENSP00000314343 | ENSP00000464330 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | 0.404 |
| SLFN12L | C18orf63 | ENSP00000437635 | ENSP00000464330 | Schlafen family member 12 like; Belongs to the Schlafen family | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 | 0.497 |
