| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACPP | KLK3 | ENSP00000323036 | ENSP00000314151 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | 0.762 |
| ACPP | KLKB1 | ENSP00000323036 | ENSP00000264690 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | Plasma kallikrein; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin; Belongs to the peptidase S1 family. Plasma kallikrein subfamily | 0.801 |
| ACPP | MSMB | ENSP00000323036 | ENSP00000463092 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | Beta-microseminoprotein; Microseminoprotein beta | 0.722 |
| ACPP | TGM4 | ENSP00000323036 | ENSP00000296125 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract; Transglutaminases | 0.755 |
| CRISP3 | KLK3 | ENSP00000389026 | ENSP00000314151 | Cysteine rich secretory protein family; Belongs to the CRISP family | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | 0.414 |
| CRISP3 | MSMB | ENSP00000389026 | ENSP00000463092 | Cysteine rich secretory protein family; Belongs to the CRISP family | Beta-microseminoprotein; Microseminoprotein beta | 0.785 |
| GZMK | MSMB | ENSP00000231009 | ENSP00000463092 | Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily | Beta-microseminoprotein; Microseminoprotein beta | 0.671 |
| KLK3 | ACPP | ENSP00000314151 | ENSP00000323036 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | 0.762 |
| KLK3 | CRISP3 | ENSP00000314151 | ENSP00000389026 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | Cysteine rich secretory protein family; Belongs to the CRISP family | 0.414 |
| KLK3 | MSMB | ENSP00000314151 | ENSP00000463092 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | Beta-microseminoprotein; Microseminoprotein beta | 0.682 |
| KLK3 | TGM4 | ENSP00000314151 | ENSP00000296125 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract; Transglutaminases | 0.623 |
| KLKB1 | ACPP | ENSP00000264690 | ENSP00000323036 | Plasma kallikrein; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin; Belongs to the peptidase S1 family. Plasma kallikrein subfamily | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | 0.801 |
| KLKB1 | MSMB | ENSP00000264690 | ENSP00000463092 | Plasma kallikrein; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin; Belongs to the peptidase S1 family. Plasma kallikrein subfamily | Beta-microseminoprotein; Microseminoprotein beta | 0.657 |
| KLKB1 | TGM4 | ENSP00000264690 | ENSP00000296125 | Plasma kallikrein; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin; Belongs to the peptidase S1 family. Plasma kallikrein subfamily | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract; Transglutaminases | 0.714 |
| MSMB | ACPP | ENSP00000463092 | ENSP00000323036 | Beta-microseminoprotein; Microseminoprotein beta | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma; Belongs to the histidine acid phosphatase family | 0.722 |
| MSMB | CRISP3 | ENSP00000463092 | ENSP00000389026 | Beta-microseminoprotein; Microseminoprotein beta | Cysteine rich secretory protein family; Belongs to the CRISP family | 0.785 |
| MSMB | GZMK | ENSP00000463092 | ENSP00000231009 | Beta-microseminoprotein; Microseminoprotein beta | Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily | 0.671 |
| MSMB | KLK3 | ENSP00000463092 | ENSP00000314151 | Beta-microseminoprotein; Microseminoprotein beta | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins | 0.682 |
| MSMB | KLKB1 | ENSP00000463092 | ENSP00000264690 | Beta-microseminoprotein; Microseminoprotein beta | Plasma kallikrein; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin; Belongs to the peptidase S1 family. Plasma kallikrein subfamily | 0.657 |
| MSMB | PRNP | ENSP00000463092 | ENSP00000368752 | Beta-microseminoprotein; Microseminoprotein beta | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degr [...] | 0.840 |
