• Version:
  • 11.0 [archived version]
STRINGSTRING
PNMAL2 PNMAL2 RBM46 RBM46 ENSG00000258818 ENSG00000258818 VSNL1 VSNL1 KNDC1 KNDC1 TPPP3 TPPP3 SNTN SNTN RSPH1 RSPH1 CHADL CHADL HSD17B2 HSD17B2 BPIFB1 BPIFB1
"TPPP3" - Tubulin polymerization-promoting protein family member 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TPPP3Tubulin polymerization-promoting protein family member 3; Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis; Tubulin polymerization promoting proteins (176 aa)    
Predicted Functional Partners:
CHADL
Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte’s differentiation by acting on its cellular collagenous microenvironment; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily (762 aa)
      
   
  0.545
VSNL1
Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family (191 aa)
            
  0.539
SNTN
Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules (147 aa)
            
  0.528
HSD17B2
Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH; Short chain dehydrogenase/reductase superfamily (387 aa)
            
  0.490
KNDC1
Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (1749 aa)
      
   
  0.469
BPIFB1
BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (484 aa)
            
  0.466
RSPH1
Radial spoke head 1 homolog; May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes (309 aa)
      
   
  0.462
PNMAL2
Paraneoplastic antigen-like protein 8B; Paraneoplastic Ma antigen family-like 2 (635 aa)
      
      0.457
ENSG00000258818
Ribonuclease 4; This RNase has marked specificity towards the 3’ side of uridine nucleotides; Ribonuclease A family (147 aa)
            
  0.451
RBM46
Probable RNA-binding protein 46; RNA binding motif containing (533 aa)
            
  0.448
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >