| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BLMH | FAM222B | ENSP00000261714 | ENSP00000462419 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity | Protein FAM222B; Family with sequence similarity 222 member B | 0.506 |
| CRYBA1 | FAM222B | ENSP00000225387 | ENSP00000462419 | Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens | Protein FAM222B; Family with sequence similarity 222 member B | 0.457 |
| FAM222B | BLMH | ENSP00000462419 | ENSP00000261714 | Protein FAM222B; Family with sequence similarity 222 member B | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity | 0.506 |
| FAM222B | CRYBA1 | ENSP00000462419 | ENSP00000225387 | Protein FAM222B; Family with sequence similarity 222 member B | Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens | 0.457 |
| FAM222B | KRIT1 | ENSP00000462419 | ENSP00000378015 | Protein FAM222B; Family with sequence similarity 222 member B | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | 0.444 |
| FAM222B | NLK | ENSP00000462419 | ENSP00000384625 | Protein FAM222B; Family with sequence similarity 222 member B | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inh [...] | 0.439 |
| FAM222B | NUFIP2 | ENSP00000462419 | ENSP00000225388 | Protein FAM222B; Family with sequence similarity 222 member B | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA | 0.511 |
| FAM222B | PDCD10 | ENSP00000462419 | ENSP00000376506 | Protein FAM222B; Family with sequence similarity 222 member B | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family | 0.443 |
| FAM222B | PHF12 | ENSP00000462419 | ENSP00000329933 | Protein FAM222B; Family with sequence similarity 222 member B | PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA | 0.442 |
| FAM222B | STAMBP | ENSP00000462419 | ENSP00000377633 | Protein FAM222B; Family with sequence similarity 222 member B | STAM-binding protein; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degr [...] | 0.455 |
| FAM222B | ZNF727P | ENSP00000462419 | ENSP00000485448 | Protein FAM222B; Family with sequence similarity 222 member B | Putative zinc finger protein 727; May be involved in transcriptional regulation | 0.491 |
| KRIT1 | FAM222B | ENSP00000378015 | ENSP00000462419 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | Protein FAM222B; Family with sequence similarity 222 member B | 0.444 |
| KRIT1 | PDCD10 | ENSP00000378015 | ENSP00000376506 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family | 0.950 |
| NLK | FAM222B | ENSP00000384625 | ENSP00000462419 | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inh [...] | Protein FAM222B; Family with sequence similarity 222 member B | 0.439 |
| NUFIP2 | FAM222B | ENSP00000225388 | ENSP00000462419 | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA | Protein FAM222B; Family with sequence similarity 222 member B | 0.511 |
| PDCD10 | FAM222B | ENSP00000376506 | ENSP00000462419 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family | Protein FAM222B; Family with sequence similarity 222 member B | 0.443 |
| PDCD10 | KRIT1 | ENSP00000376506 | ENSP00000378015 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and va [...] | 0.950 |
| PHF12 | FAM222B | ENSP00000329933 | ENSP00000462419 | PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA | Protein FAM222B; Family with sequence similarity 222 member B | 0.442 |
| STAMBP | FAM222B | ENSP00000377633 | ENSP00000462419 | STAM-binding protein; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degr [...] | Protein FAM222B; Family with sequence similarity 222 member B | 0.455 |
| ZNF727P | FAM222B | ENSP00000485448 | ENSP00000462419 | Putative zinc finger protein 727; May be involved in transcriptional regulation | Protein FAM222B; Family with sequence similarity 222 member B | 0.491 |
